Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce symmetric undulation.
Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce symmetric undulation.
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DOI：
10.1016/j.cub.2022.09.002
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发表时间：
2022-11-07
期刊：
影响因子：
9.2
通讯作者：
Zhen, Mei
中科院分区：
文献类型：
--
作者：
Lu, Yangning;Ahamed, Tosif;Mulcahy, Ben;Meng, Jun;Witvliet, Daniel;Guan, Sihui Asuka;Holmyard, Douglas;Hung, Wesley;Wen, Quan;Chisholm, Andrew D.;Samuel, Aravinthan D. T.;Zhen, Mei
In many animals, there is a direct correspondence between the motor patterns that drive locomotion and the motor neuron innervation. For example, the adult C. elegans moves with symmetric and alternating dorsal-ventral bending waves arising from symmetric motor neuron input onto the dorsal and ventral muscles. In contrast to the adult, the C. elegans motor circuit at the juvenile larval stage has asymmetric wiring between motor neurons and muscles, but still generates adult-like bending waves with dorsal-ventral symmetry. We show that in the juvenile circuit, wiring between excitatory and inhibitory motor neurons coordinates the contraction of dorsal muscles with relaxation of ventral muscles, producing dorsal bends. However, ventral bending is not driven by analogous wiring. Instead, ventral muscles are excited uniformly by premotor interneurons through extrasynaptic signaling. Ventral bends occur in anti-phasic entrainment to activity of the same motor neurons that drive dorsal bends. During maturation, the juvenile motor circuit is replaced by two motor subcircuits that separately drive dorsal and ventral bending. Modeling reveals that the juvenile’s immature motor circuit is an adequate solution to generate adult-like dorsal-ventral bending before the animal matures. Developmental rewiring between functionally degenerate circuit solutions, that both generate symmetric bending patterns, minimizes behavioral disruption across maturation. A newborn worm’s motor circuit is asymmetric, wired to only make dorsal bends. Yet, they make dorsoventral undulations. Lu, Ahamed et al. show that ventral bends happen by a tonic potentiation of ventral muscles by cholinergic premotor interneurons and anti-phasic entrainment to the dorsal bends.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
48
作者：
Kim CK;Yang SJ;Pichamoorthy N;Young NP;Kauvar I;Jennings JH;Lerner TN;Berndt A;Lee SY;Ramakrishnan C;Davidson TJ;Inoue M;Bito H;Deisseroth K
通讯作者：
Deisseroth K
影响因子：
48
作者：
Guo, Zengcai V.;Hart, Anne C.;Ramanathan, Sharad
通讯作者：
Ramanathan, Sharad
影响因子：
10.1
作者：
Gjorgjieva J;Biron D;Haspel G
通讯作者：
Haspel G
DOI：
10.1523/jneurosci.0378-08.2008
发表时间：
2008-07-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dittman JS;Kaplan JM
通讯作者：
Kaplan JM