Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain.
Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain.
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DOI：
10.1038/nmeth.3770
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发表时间：
2016-04
期刊：
影响因子：
48
通讯作者：
Deisseroth K
中科院分区：
文献类型：
--
作者：
Kim CK;Yang SJ;Pichamoorthy N;Young NP;Kauvar I;Jennings JH;Lerner TN;Berndt A;Lee SY;Ramakrishnan C;Davidson TJ;Inoue M;Bito H;Deisseroth K
来自多个特定细胞群和投射的实时活动测量对于理解大脑作为一个动力学系统可能是重要的。在这里，我们开发了帧投射独立纤维光度法（FIP），我们用来记录荧光活动信号，同时从许多大脑区域在自由行为的小鼠。我们探索了FIP显微镜的多功能性，通过量化社会行为过程中许多大脑区域之间的实时活动关系，同时记录感官体验过程中沿着多个轴突通路的活动，同时进行双色活动记录，并应用光学微扰调谐以引起与行为过程中观察到的自然发生的模式相匹配的动态。
Real-time activity measurements from multiple specific cell populations and projections are likely to be important for understanding the brain as a dynamical system. Here we developed frame-projected independent-fiber photometry (FIP), which we used to record fluorescence activity signals from many brain regions simultaneously in freely behaving mice. We explored the versatility of the FIP microscope by quantifying real-time activity relationships among many brain regions during social behavior, simultaneously recording activity along multiple axonal pathways during sensory experience, performing simultaneous two-color activity recording, and applying optical perturbation tuned to elicit dynamics that match naturally occurring patterns observed during behavior.
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