Human immunodeficiency virus DNA is present in a high percentage of CD4+ lymphocytes of seropositive individuals.
Human immunodeficiency virus DNA is present in a high percentage of CD4+ lymphocytes of seropositive individuals.
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人类免疫缺陷病毒 DNA 存在于血清阳性个体的高比例 CD4 淋巴细胞中。
DOI：
10.1093/infdis/164.3.470
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Spector,SA
中科院分区：
文献类型：
--
作者：
Hsia,K;Spector,SA
人类免疫缺陷病毒1型（HIV-I）主要感染人外周血中的CD4+细胞，感染与艾滋病患者的CD4+淋巴细胞功能障碍有关。为了确定体内CD4+淋巴细胞感染HIV-I的频率，采用荧光活化细胞分选方法从无症状到艾滋病临床疾病的HIV-I感染者外周血中分离CD4+淋巴细胞。使用标准聚合酶链反应和增强聚合酶链反应分析，研究发现艾滋病和艾滋病相关复合体（ARC）患者在至少10%的CD4+淋巴细胞中携带hiv - 1基因组，在无症状感染者中发现感染细胞减少了1 / 4。此外，ARC患者外周血单个核细胞中hiv - 1感染的CD4+淋巴细胞的绝对数量往往高于艾滋病患者或无症状感染者。CD4+淋巴细胞的高水平感染可能是HIV-1感染患者出现进行性免疫缺陷的主要原因。
Human immunodeficiency virus type 1 (HIV-I) infects predominantly CD4+cells in human peripheral blood and infection is associated with CD4+lymphocyte dysfunction in patients with AIDS. To determine the frequency of HIV-I infection in CD4+lymphocytes in vivo, peripheral blood CD4+lymphocytes were isolated by fluorescence-activated cell sorting from HIV-I-infected persons with clinical disease ranging from asymptomatic to AIDS. Using standard and booster polymerase chain reaction analyses, study patients with AIDS and AIDS-related complex (ARC) were found to harbor the HIV-I genome in at least 10% of CD4+lymphocytes, and -to-fold less infected cells were found in those with asymptomatic infection. In addition, the peripheral blood mononuclear cells from patients with ARC frequently contained a higher absolute number of HIV-l-infected CD4+lymphocytes than those with AIDS or asymptomatic infection. It is likely that this high level of infection of CD4+lymphocytes is the primary cause for the progressive immunologic deficiencyobserved in patients infected with HIV-1.
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影响因子：
39.2
作者：
SCHNITTMAN, SM;GREENHOUSE, JJ;LANE, HC
通讯作者：
LANE, HC
人类逆转录病毒 HTLV-III/LAV 的细胞趋向性。
影响因子：
4.4
作者：
J. Mcdougal;A. Mawle;S. Cort;J. Nicholson;G. Cross;J. A. Scheppler;D. Hicks;J. Sligh
通讯作者：
J. Sligh
影响因子：
4.4
作者：
K. Clouse;D. Powell;I. Washington;Guido Poli;K. Strebel;W. Farrar;P. Barstad;J. Kovacs;A. Fauci;T. Folks
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K. Clouse;D. Powell;I. Washington;Guido Poli;K. Strebel;W. Farrar;P. Barstad;J. Kovacs;A. Fauci;T. Folks
人类免疫缺陷病毒和获得性免疫缺陷综合症：相关但不是因果关系。
DOI：
10.1073/pnas.86.3.755
发表时间：
1989
影响因子：
11.1
作者：
Duesberg,PH
通讯作者：
Duesberg,PH
人类嗜 T 淋巴细胞病毒 III 型 (HTLV-III) 的基因组多样性。
影响因子：
56.9
作者：
F. Wong;G. Shaw;B. Hahn;S. Salahuddin;M. Popovič;P. Markham;R. Redfield;R. Gallo
通讯作者：
R. Gallo