A novel lncRNA-miRNA-mRNA competing endogenous RNA regulatory network in lung adenocarcinoma and kidney renal papillary cell carcinoma.
A novel lncRNA-miRNA-mRNA competing endogenous RNA regulatory network in lung adenocarcinoma and kidney renal papillary cell carcinoma.
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肺腺癌和肾乳头状细胞癌中新型lncRNA-miRNA-mRNA竞争性内源RNA调节网络
DOI：
10.1111/1759-7714.14129
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发表时间：
2021-10
期刊：
影响因子：
2.9
通讯作者：
Jin M
中科院分区：
文献类型：
--
作者：
Zhou Q;Li D;Zheng H;He Z;Qian F;Wu X;Yin Z;Bao PT;Jin M
GPRIN 1可能是一种新的肿瘤调节因子，但其在肿瘤中的作用和机制尚不清楚。首先，基于从癌症基因组图谱（TCGA）数据库下载的数据，对GPRIN 1的表达和预后进行泛癌症相关性分析。其次，利用Starbase数据库预测GPRIN 1上游miRNAs和lncRNAs，并进行表达分析、生存分析和相关性分析，筛选与肾乳头状细胞癌（KIRP）或肺腺癌（LUAD）相关的microRNA（miRNAs）/长链非编码RNA（lncRNAs）。第三，采用CIBERSORT算法计算各种类型免疫细胞的比例，然后使用R包评估GPRIN 1表达与肿瘤免疫细胞浸润以及GPRIN 1与免疫细胞生物标志物之间的关系。最后对GPRIN 1与免疫检查点（CD 274、CTLA 4、PDCD 1）进行相关性分析。泛癌分析表明，GPRIN 1在KIRP和LUAD中表达上调，与预后不良相关。LINC 00894/MMP 25-AS 1/SNHG 1/LINC 02298/MIR 193 BHG-miR-140 - 3 p可能是GPRIN 1最有希望的上游调控途径。LINC 00894/MMP 25-AS 1/SNHG 1/LINC 02298/MIR 193 BHG的高表达和miR-140 - 3 p的低表达与KIRP和LUAD的不良结局相关。GPRIN 1表达与肿瘤免疫细胞浸润、免疫细胞生物标志物和免疫检查点显著相关。miR-140 - 3 p-GPRIN 1轴的竞争性内源性（ceRNA）及其上游lncRNA与KIRP和LUAD密切相关，可能影响KIRP和LUAD的预后和治疗效果。GPRIN 1是KIRP和LUAD的重要预后标志物。ncRNA（LINC 00894/MMP 25-AS 1/SNHG 1/LINC 02298/MIR 193 BHG）介导的GPRIN 1高表达与KIPR和LUAD的不良预后和肿瘤免疫浸润相关。
GPRIN1 may be a novel tumor regulator, but its role and mechanism in tumors are still unclear. First, a pan‐cancer correlation analysis was conducted on the expression and prognosis of GPRIN1 based on the data downloaded from The Cancer Genome Atlas (TCGA) database. Second, the Starbase database was used to predict the upstream miRNAs and lncRNAs of GPRIN1, and the expression analysis, survival analysis, and correlation analysis were performed to screen the microRNA (miRNAs)/long non‐coding RNAs (lncRNAs) that had a correlation with kidney renal papillary cell carcinoma (KIRP) or lung adenocarcinoma (LUAD). Third, the CIBERSORT algorithm was employed to calculate the proportion of various types of immune cells, and then the R packages were used for evaluating the relation between GPRIN1 expression and tumor immune cell infiltration as well as between GPRIN1 and the immune cell biomarker. Finally, the correlation analysis was made on GPRIN1 and immune checkpoints (CD274, CTLA4, and PDCD1). The pan‐cancer analysis suggested that GPRIN1 was up‐expressed in KIRP and LUAD, and it correlated with poor prognosis. LINC00894/MMP25‐AS1/SNHG1/LINC02298/MIR193BHG‐miR‐140‐3p was likely to be the most promising upstream regulation pathway of GPRIN1. Upexpression of LINC00894/MMP25‐AS1/SNHG1/LINC02298/MIR193BHG and downexpression of miR‐140‐3p were found relevant with poor outcomes of KIRP and LUAD. GPRIN1 expression was significantly correlated with tumor immune cell infiltration, immune cell biomarkers, and immune checkpoints. The competitive endogenous (ceRNA) of miR‐140‐3p‐GPRIN1 axis and its upstream lncRNAs are closely related to KIRP and LUAD, and might affect the prognosis and therapeutic effect of KIRP and LUAD. GPRIN1 is an important prognostic marker for KIRP and LUAD. ncRNA (LINC00894/MMP25‐AS1/SNHG1/LINC02298/MIR193BHG)‐mediated high expression of GPRIN1 correlates with poor prognosis and tumor immune infiltration of KIPR and LUAD.
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DOI：
10.26355/eurrev_202003_20661
发表时间：
2020-03-01
影响因子：
3.3
作者：
Zhang, Y-J;Lu, C.
通讯作者：
Lu, C.
影响因子：
--
作者：
Chen Y;Zhang W;Shen L;Kadier A;Huang J;Wang R;Wu P;Yao X
通讯作者：
Yao X
影响因子：
5.2
作者：
Kinget L;Roussel E;Verbiest A;Albersen M;Rodríguez-Antona C;Graña-Castro O;Inglada-Pérez L;Zucman-Rossi J;Couchy G;Job S;de Reyniès A;Laenen A;Baldewijns M;Beuselinck B
通讯作者：
Beuselinck B
影响因子：
4
作者：
Meng DF;Shao H;Feng CB
通讯作者：
Feng CB
DOI：
10.1152/ajplung.00334.2018
发表时间：
2019-05-01
影响因子：
4.9
作者：
Gao, Li-Ming;Zheng, Yue;Xu, Shu-Feng
通讯作者：
Xu, Shu-Feng