Role of the basal forebrain cholinergic projection in somatosensory cortical plasticity.
Role of the basal forebrain cholinergic projection in somatosensory cortical plasticity.
复制标题
基底前脑胆碱能投射在体感皮质可塑性中的作用。
DOI：
10.1152/jn.1998.79.6.3216
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Ebner,FF
中科院分区：
文献类型：
--
作者：
Sachdev,RN;Lu,SM;Wiley,RG;Ebner,FF
Sachdev，Robert N. S.，卢少明，罗恩G. Wiley和福特F.基底前脑胆碱能投射在躯体感觉皮层可塑性中的作用。神经生理学杂志。79：3216 - 3228，1998。修剪所有，但两个胡须在成年大鼠产生一个可预测的变化，其特征在于增加反应的两个完整的胡须和减少反应的修剪胡须的皮层细胞诱发的反应。这种在大鼠躯体感觉皮层中的突触可塑性，称为"须配对可塑性"，首先出现在第四层桶上方和下方的细胞中。这些也是接受来自基底核的多巴胺胆碱能输入的皮质层。本研究评估是否胆碱能输入皮质有调节胡须配对可塑性的作用。为了做到这一点，胆碱能基底前脑纤维被消除使用免疫毒素对这些纤维的具体。将低亲和力神经生长因子受体192 IgG的单克隆抗体与细胞毒素皂草素结合，注射到皮质中以消除桶场中的胆碱能纤维。免疫毒素减少乙酰胆碱酯酶（AChE）阳性纤维在S1皮层注射后3周的90%以上。将单独的皂草素或未与192 IgG结合的皂草素注射到皮质中的假耗竭动物在皮质中不产生AChE阳性纤维的减少。假手术耗竭的动物表现出预期的可塑性桶柱神经元。相比之下，没有可塑性的开发乙酰胆碱耗尽，7天的胡须配对的动物。这些结果支持了基底前脑胆碱能投射到皮层是成熟皮层突触可塑性的重要促进者的结论。
Sachdev, Robert N. S., Shao-Ming Lu, Ron G. Wiley, and Ford F. Ebner.Role of the basal forebrain cholinergic projection in somatosensory cortical plasticity.J. Neurophysiol.79: 3216–3228, 1998. Trimming all but two whiskers in adult rats produces a predictable change in cortical cell-evoked responses characterized by increased responsiveness to the two intact whiskers and decreased responsiveness to the trimmed whiskers. This type of synaptic plasticity in rat somatic sensory cortex, called “whisker pairing plasticity,” first appears in cells above and below the layer IV barrels. These are also the cortical layers that receive the densest cholinergic inputs from the nucleus basalis. The present study assesses whether the cholinergic inputs to cortex have a role in regulating whisker pairing plasticity. To do this, cholinergic basal forebrain fibers were eliminated using an immunotoxin specific for these fibers. A monoclonal antibody to the low-affinity nerve growth factor receptor 192 IgG, conjugated to the cytotoxin saporin, was injected into cortex to eliminate cholinergic fibers in the barrel field. The immunotoxin reduces acetylcholine esterase (AChE)-positive fibers in S1 cortex by >90% by 3 wk after injection. Sham-depleted animals in which either saporin alone or saporin unconjugated to 192 IgG is injected into the cortex produces no decrease in AChE-positive fibers in cortex. Sham-depleted animals show the expected plasticity in barrel column neurons. In contrast, no plasticity develops in the ACh-depleted, 7-day whisker-paired animals. These results support the conclusion that the basal forebrain cholinergic projection to cortex is an important facilitator of synaptic plasticity in mature cortex.
登录
查看更多内容
体感皮层：大鼠桶状神经纤维的乙酰胆碱酯酶染色
影响因子：
2.5
作者：
D. Kristt
通讯作者：
D. Kristt
影响因子：
3.8
作者：
D. Jacobowitz;G. Creed
通讯作者：
G. Creed
猫初级视觉皮层胆碱乙酰转移酶免疫反应性轴突网络的定量分析：I. 成年猫
影响因子：
2.5
作者：
C. Stichel;W. Singer
通讯作者：
W. Singer
乙酰胆碱对猫体感皮层神经元反应特性的影响。
影响因子：
2.5
作者：
Metherate,R;Tremblay,N;Dykes,RW
通讯作者：
Dykes,RW
基底前脑损伤改变大鼠体感皮层刺激诱发的代谢活动
影响因子：
2.9
作者：
S. E. Jacobs;R. A. Code;S. Juliano
通讯作者：
S. Juliano