Antibodies against N-methyl-D-aspartate receptors in patients with systemic lupus erythematosus without major neuropsychiatric syndromes.
Antibodies against N-methyl-D-aspartate receptors in patients with systemic lupus erythematosus without major neuropsychiatric syndromes.
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DOI：
10.1016/j.jns.2010.04.016
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发表时间：
2010-08-15
影响因子：
4.4
通讯作者：
Zhang, Lening
中科院分区：
文献类型：
--
作者：
Kozora, Elizabeth;West, Sterling G.;Maier, Steven F.;Filley, Christopher M.;Arciniegas, David B.;Brown, Mark;Miller, David;Grimm, Alex;Zhang, Lening
大约14-54%的无主要神经精神综合征（nonNPSLE）病史的系统性红斑狼疮患者有认知缺陷。据报道，35%的SLE患者的N-甲基-D-天冬氨酸（NMDA）受体抗体（抗NR 2）升高，但很少有研究使用对照或复合记忆指数。我们假设，与健康对照组相比，非NPSLE患者血清抗NR 2抗体升高，抗NR 2抗体升高与记忆功能障碍和抑郁症相关。受试者包括43名非NPSLE患者，平均年龄为36.5岁（SD=9.0），平均教育水平为14.7年（SD=2.5）。本研究还招募了27名具有相似人口统计学特征的健康对照受试者。使用ACR-SLE神经心理成套测验的受损测试分数计算整体认知障碍指数（CII）和记忆障碍指数（MII）。使用标准ELISA分析血清样品的抗NR 2。在14.0%的非NPSLE和7.4%的对照组中发现血清抗NR 2升高（p=0.47）。抗NR 2状态升高与较高的CII或MII表现之间没有关系。抗NR 2抗体升高的频率较低（14.0%），与对照组相比无显著性差异。血清中抗NR 2的存在与整体认知或记忆指数或抑郁症之间没有关系。结果表明，血清抗NR 2不太可能与轻度认知功能障碍的SLE患者没有NPSLE的既往史。
Approximately 14-54% of patients with systemic lupus erythematosus without a history of major neuropsychiatric syndromes (nonNPSLE) have cognitive deficits. Elevated N-methyl-D-aspartate (NMDA) receptor antibodies (anti-NR2) have been reported in 35% of patients with SLE, but few studies have utilized controls or a composite memory index. We hypothesized that serum anti-NR2 would be elevated in nonNPSLE compared to healthy controls, and that elevated anti-NR2 would be associated with memory dysfunction and depression. Subjects included 43 nonNPSLE patients with a mean age of 36.5 (SD=9.0) and mean education level of 14.7 years (SD=2.5). Twenty-seven healthy control subjects with similar demographic characteristics were also enrolled in this study. A global cognitive impairment index (CII) and a memory impairment index (MII) were calculated using impaired test scores from the ACR-SLE neuropsychological battery. Serum samples were analyzed using a standard ELISA for anti-NR2. Elevations of serum anti-NR2 were found in 14.0% of the nonNPSLE and 7.4% of the controls (p=0.47). There was no relationship between elevated anti-NR2 status and higher CII or performance on the MII. No relationship between levels of depressive symptoms and anti-NR2 was found. The frequency of elevated anti-NR2 was low (14.0%) in this sample of SLE patients and not significantly different from controls. A relationship was not found between the presence of anti-NR2 in serum and global cognitive or memory indices, or with depression. Results suggest that serum anti-NR2 is not likely related to mild cognitive dysfunction in SLE patients without a prior history of NPSLE.
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DOI：
10.1073/pnas.0608397104
发表时间：
2006-12-26
影响因子：
11.1
作者：
Kowal, Czeslawa;DeGiorgio, Lorraine A.;Diamond, Betty
通讯作者：
Diamond, Betty
影响因子：
--
作者：
Kozora, E;Thompson, LL;Kotzin, BL
通讯作者：
Kotzin, BL
影响因子：
--
作者：
Arinuma, Yoshiyuki;Yanagida, Tamiko;Hirohata, Shunsei
通讯作者：
Hirohata, Shunsei
影响因子：
--
作者：
HAY, EM;BLACK, D;HOLT, PJL
通讯作者：
HOLT, PJL
影响因子：
--
作者：
BOMBARDIER, C;GLADMAN, DD;CHANG, CH
通讯作者：
CHANG, CH