Maternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: a population-based nationwide study in Sweden.
Maternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: a population-based nationwide study in Sweden.
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DOI：
10.1038/mp.2015.183
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发表时间：
2016-10
影响因子：
11
通讯作者：
Gardner, R. M.
中科院分区：
文献类型：
--
作者：
Kosidou, K.;Dalman, C.;Widman, L.;Arver, S.;Lee, B. K.;Magnusson, C.;Gardner, R. M.
尽管许多研究表明遗传和环境因素在自闭症谱系障碍（ASD）的病因学中相互作用，但我们对其潜在机制的了解有限，阻碍了检测和预防该疾病的有效方法的开发。最近的研究支持这样的假设：产前雄激素暴露会导致自闭症谱系障碍（ASD）的发生。这表明母亲多囊卵巢综合征（PCOS）（一种与过量雄激素相关的疾病）会增加后代患自闭症谱系障碍（ASD）的风险。我们针对瑞典总人口（1984 年至 2007 年在瑞典出生的 4 至 17 岁儿童）进行了一项匹配的病例对照研究。样本由 23 748 名 ASD 病例和 208 796 名对照组成，并按出生月份和年份、性别和出生地区进行匹配。 PCOS 和 ASD 是通过与医疗保健登记册的链接根据 ICD 代码定义的。调整混杂因素后，母亲 PCOS 使后代患 ASD 的几率增加 59%（优势比 (OR) 1.59，95% 置信区间 (CI) 1.34–1.88）。在同时患有 PCOS 和肥胖的母亲中，后代 ASD 的几率进一步增加，肥胖是 PCOS 的常见病症，与更严重的高雄激素血症相关（OR 2.13，95% CI 1.46-3.10）。风险估计在性别之间没有差异。总之，患有 PCOS 的女性的孩子似乎有更高的风险患上自闭症谱系障碍 (ASD)。这一发现有待证实，并探索潜在的潜在机制，包括性类固醇在自闭症谱系障碍病因学中的作用。
Although many studies indicate the interplay of genetic and environmental factors in the etiology of autism spectrum disorder (ASD), our limited understanding of the underlying mechanisms hampers the development of effective ways of detecting and preventing the disorder. Recent studies support the hypothesis that prenatal androgen exposure contributes to the development of ASD. This would suggest that maternal polycystic ovary syndrome (PCOS), a condition associated with excess androgens, would increase the risk of ASD in the offspring. We conducted a matched case–control study nested within the total population of Sweden (children aged 4–17 who were born in Sweden from 1984 to 2007). The sample consisted of 23 748 ASD cases and 208 796 controls, matched by birth month and year, sex and region of birth. PCOS and ASD were defined from ICD codes through linkage to health-care registers. Maternal PCOS increased the odds of ASD in the offspring by 59%, after adjustment for confounders (odds ratio (OR) 1.59, 95% confidence interval (CI) 1.34–1.88). The odds of offspring ASD were further increased among mothers with both PCOS and obesity, a condition common to PCOS that is related to more severe hyperandrogenemia (OR 2.13, 95% CI 1.46–3.10). Risk estimates did not differ between sexes. In conclusion, children of women with PCOS appear to have a higher risk of developing ASD. This finding awaits confirmation, and exploration of potentially underlying mechanisms, including the role of sex steroids in the etiology of ASD.
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影响因子：
5.8
作者：
Anderson, Helen;Fogel, Naomi;Dunaif, Andrea
通讯作者：
Dunaif, Andrea
影响因子：
3.3
作者：
Bringas, M. E.;Carvajal-Flores, F. N.;Flores, G.
通讯作者：
Flores, G.
影响因子：
158.5
作者：
EHRMANN, DA;ROSENFIELD, RL;SHEIKH, Z
通讯作者：
SHEIKH, Z
影响因子：
3.7
作者：
Albu, Alice;Radian, Serban;Barbu, Carmen Gabriela
通讯作者：
Barbu, Carmen Gabriela
DOI：
10.1016/0002-9378(86)90746-5
发表时间：
1986-05-01
影响因子：
9.8
作者：
BARBIERI, RL;SALTZMAN, DH;RYAN, KJ
通讯作者：
RYAN, KJ