Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases.
Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases.
复制标题
DOI：
10.3389/fphar.2021.762654
复制
发表时间：
2021
影响因子：
5.6
通讯作者：
Meng X
中科院分区：
文献类型：
--
作者：
Ai X;Yu P;Peng L;Luo L;Liu J;Li S;Lai X;Luan F;Meng X
中医药在各种疾病的治疗中发挥着重要作用，越来越受到临床应用的重视。影响心脏血管系统的血管疾病、脑血管疾病、动脉粥样硬化和糖尿病并发症损害了受影响个人的生活质量，增加了卫生保健服务的负担。黄连中的黄连素是一种天然存在的异喹啉生物碱，因其抗菌、抗炎等药理作用，在中国民间被广泛使用。令人振奋的是，越来越多的研究已经确定了黄连素的几个细胞和分子靶点，表明了它作为血管疾病替代治疗策略的潜力，并提供了新的证据，支持黄连素治疗血管疾病的潜力。本文就黄连素在血管疾病中的药理作用、分子机制、药代动力学等方面的研究进展作一综述。目前已发表的研究资料表明，黄连素具有显著的抗炎、抗氧化、抗细胞凋亡和抗自噬作用，其机制涉及多条信号通路，包括AMPK、核因子κB、丝裂原激活蛋白激酶沉默信息调节因子1、缺氧诱导因子1α、血管内皮生长因子磷脂酰肌醇3-激酶、蛋白激酶B、肌动蛋白激酶2、钙通道和内质网应激等。此外，我们还讨论了黄连素在治疗血管疾病方面存在的局限性，并给出了相应的措施。此外，我们还提出了一些研究前景和挑战，为进一步研究从中药单体中挖掘新的有效药物提供了坚实的证据基础。
Traditional Chinese medicine plays a significant role in the treatment of various diseases and has attracted increasing attention for clinical applications. Vascular diseases affecting vasculature in the heart, cerebrovascular disease, atherosclerosis, and diabetic complications have compromised quality of life for affected individuals and increase the burden on health care services. Berberine, a naturally occurring isoquinoline alkaloid form Rhizoma coptidis, is widely used in China as a folk medicine for its antibacterial and anti-inflammatory properties. Promisingly, an increasing number of studies have identified several cellular and molecular targets for berberine, indicating its potential as an alternative therapeutic strategy for vascular diseases, as well as providing novel evidence that supports the therapeutic potential of berberine to combat vascular diseases. The purpose of this review is to comprehensively and systematically describe the evidence for berberine as a therapeutic agent in vascular diseases, including its pharmacological effects, molecular mechanisms, and pharmacokinetics. According to data published so far, berberine shows remarkable anti-inflammatory, antioxidant, antiapoptotic, and antiautophagic activity via the regulation of multiple signaling pathways, including AMP-activated protein kinase (AMPK), nuclear factor κB (NF-κB), mitogen-activated protein kinase silent information regulator 1 (SIRT-1), hypoxia-inducible factor 1α (HIF-1α), vascular endothelial growth factor phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), janus kinase 2 (JAK-2), Ca2+ channels, and endoplasmic reticulum stress. Moreover, we discuss the existing limitations of berberine in the treatment of vascular diseases, and give corresponding measures. In addition, we propose some research perspectives and challenges, and provide a solid evidence base from which further studies can excavate novel effective drugs from Chinese medicine monomers.
登录
查看更多内容
影响因子：
--
作者：
Cheng YC;Sheen JM;Hu WL;Hung YC
通讯作者：
Hung YC
影响因子：
8.6
作者：
Banerjee P;Siramshetty VB;Drwal MN;Preissner R
通讯作者：
Preissner R
影响因子：
5.5
作者：
Al Rifai, Mahmoud;Mahtta, Dhruv;Virani, Salim S.
通讯作者：
Virani, Salim S.
藏药方吉坎明目滴剂改善糖尿病db/db小鼠干眼症的研究
影响因子：
5.4
作者：
Ai, Xiaopeng;Hou, Ya;Li, Qi'en
通讯作者：
Li, Qi'en
影响因子：
39.3
作者：
Ajjan RA;Kietsiriroje N;Badimon L;Vilahur G;Gorog DA;Angiolillo DJ;Russell DA;Rocca B;Storey RF
通讯作者：
Storey RF