Using whole-brain diffusion tensor analysis to evaluate white matter structural correlates of delayed visuospatial memory and one-week motor skill retention in nondemented older adults: A preliminary study.
Using whole-brain diffusion tensor analysis to evaluate white matter structural correlates of delayed visuospatial memory and one-week motor skill retention in nondemented older adults: A preliminary study.
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DOI：
10.1371/journal.pone.0274955
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
技能保留对运动康复的结果很重要。最近的研究表明，延迟的视觉空间记忆表现可以预测老年和神经病理人群中的运动技能保留。顶叶和额叶皮质之间的白质完整性可以解释上肢运动学习任务和视觉空间过程的差异。我们进行了一项全脑分析，以确定白质与非痴呆老年人延迟视觉空间记忆和一周运动技能保留的相关性。我们假设，更好的额顶束完整性将与更好的行为表现呈正相关。19名参与者(年龄58岁)完成了扩散加权成像，然后进行了延迟视觉空间记忆的临床测试和50项上肢运动任务的训练试验；一周后，参与者被重新测试了运动任务。主成分分析被用来为每个参与者的行为数据创建一个综合分数，即延迟视觉空间记忆和运动技能保持之间的共同方差，然后将其输入基于体素的回归分析。行为学结果表明，参与者在不练习一周后学习并保持了他们的技能水平，他们的延迟视觉空间记忆得分与技能保持的程度呈正相关。与以前的工作一致，神经成像结果表明，双侧丘脑前部辐射、皮质脊髓束和上纵束内的区域与更好的延迟视觉空间记忆和技能保持有关。这项研究的结果表明，在治疗前测试特定认知障碍的简单行为可能会识别出那些从运动康复方案中几乎没有受益的老年人，这些神经区域可能是治疗干预的潜在目标。
Skill retention is important for motor rehabilitation outcomes. Recent work has demonstrated that delayed visuospatial memory performance may predict motor skill retention in older and neuropathological populations. White matter integrity between parietal and frontal cortices may explain variance in upper-extremity motor learning tasks and visuospatial processes. We performed a whole-brain analysis to determine the white matter correlates of delayed visuospatial memory and one-week motor skill retention in nondemented older adults. We hypothesized that better frontoparietal tract integrity would be positively related to better behavioral performance. Nineteen participants (age>58) completed diffusion-weighted imaging, then a clinical test of delayed visuospatial memory and 50 training trials of an upper-extremity motor task; participants were retested on the motor task one week later. Principal component analysis was used to create a composite score for each participant’s behavioral data, i.e. shared variance between delayed visuospatial memory and motor skill retention, which was then entered into a voxel-based regression analysis. Behavioral results demonstrated that participants learned and retained their skill level after a week of no practice, and their delayed visuospatial memory score was positively related to the extent of skill retention. Consistent with previous work, neuroimaging results indicated that regions within bilateral anterior thalamic radiations, corticospinal tracts, and superior longitudinal fasciculi were related to better delayed visuospatial memory and skill retention. Results of this study suggest that the simple act of testing for specific cognitive impairments prior to therapy may identify older adults who will receive little to no benefit from the motor rehabilitation regimen, and that these neural regions may be potential targets for therapeutic intervention.
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DOI：
10.1097/npt.0b013e3182a3d353
发表时间：
2014-07
期刊：
Journal of neurologic physical therapy : JNPT
影响因子：
--
作者：
Borich MR;Brown KE;Boyd LA
通讯作者：
Boyd LA
影响因子：
2.5
作者：
HORAK, FB;DIENER, HC
通讯作者：
DIENER, HC
影响因子：
4.8
作者：
Bastian AJ
通讯作者：
Bastian AJ
影响因子：
4.2
作者：
Coutu JP;Chen JJ;Rosas HD;Salat DH
通讯作者：
Salat DH
DOI：
10.1097/phm.0000000000000791
发表时间：
2018-01
影响因子：
3
作者：
Cirstea CM;Lee P;Craciunas SC;Choi IY;Burris JE;Nudo RJ
通讯作者：
Nudo RJ