Inhalation cancer risk associated with exposure to complex polycyclic aromatic hydrocarbon mixtures in an electronic waste and urban area in South China.
Inhalation cancer risk associated with exposure to complex polycyclic aromatic hydrocarbon mixtures in an electronic waste and urban area in South China.
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DOI：
10.1021/es302272a
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发表时间：
2012-09-04
影响因子：
11.4
通讯作者：
Simonich, Staci L. Massey
中科院分区：
文献类型：
--
作者：
Wang, Jing;Chen, Shejun;Tian, Mi;Zheng, Xiaobo;Gonzales, Leah;Ohura, Takeshi;Mai, Bixian;Simonich, Staci L. Massey
于2010年5月至2011年4月在广州市农村电子废物区和中国南部采集了大气颗粒物样本，以评估接触母体多环芳烃(PAHs)、高相对分子质量多环芳烃(Mw 302 PAHs)和卤代多环芳烃(HPAHs)的终身吸入性癌症风险。电子垃圾和城市地区内部和之间的多环芳烃浓度和分布的季节变化表明，这两个地区的多环芳烃来源不同。苯并[b]荧菲、苯并[a]苯、二苯并[啊]蒽和二苯并[铝]芘对吸入性癌症风险的贡献最大。Mw 302多环芳烃占电子废物区总致癌风险的18.0%，占市区总致癌风险的13.6%，而HPAHs在这两个地区的贡献很小(<；0.1%)。在电子垃圾地区，因接触母体多环芳烃、相对分子质量302多环芳烃和HPAHs而导致的终生过量肺癌的数量在每百万人15.1到1198人之间，在广州每百万人从9.3到737人。多环芳烃暴露占广州市肺癌总病例的0.02~1.94%。平均而言，电子垃圾地区的吸入性癌症风险是城市地区的1.6倍。中国南部的电子垃圾拆解活动导致多环芳烃暴露导致的吸入性癌症风险高于市区。
Atmospheric particulate matter samples were collected from May 2010 to April 2011 in a rural e-waste area and in Guangzhou, South China, to estimate the lifetime inhalation cancer risk from exposure to parent polycyclic aromatic hydrocarbons (PAHs), high molecular weight PAHs (MW 302 PAHs), and halogenated PAHs (HPAHs). Seasonal variations in the PAH concentrations and profile within and between the e-waste and urban areas indicated different PAH sources in the two areas. Benzo[b]fluoranthene, BaP, dibenz[ah]anthracene, and dibenzo[al]pyrene made the most significant contribution to the inhalation cancer risk. MW 302 PAHs accounting for 18.0% of the total cancer risk in the e-waste area and 13.6% in the urban area, while HPAHs made a minor contribution (< 0.1%) in both the areas. The number of lifetime excess lung cancers due to exposure to parent PAHs, MW 302 PAHs, and HPAHs ranged from 15.1 to 1198 per million people in the e-waste area and from 9.3 to 737 per million people in Guangzhou. PAH exposure accounted for 0.02 to 1.94% of the total lung cancer cases in Guangzhou. On average, the inhalation cancer risk in the e-waste area was 1.6 times higher than in the urban area. The e-waste dismantling activities in South China led to higher inhalation cancer risk due to PAH exposure than the urban area.
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