Functional properties of the HIV-1 subtype C envelope glycoprotein associated with mother-to-child transmission.
Functional properties of the HIV-1 subtype C envelope glycoprotein associated with mother-to-child transmission.
复制标题
HIV-1 C 亚型包膜糖蛋白与母婴传播相关的功能特性。
DOI：
10.1016/j.virol.2009.12.019
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发表时间：
2010-05-10
期刊：
影响因子：
3.7
通讯作者：
Wood C
中科院分区：
文献类型：
--
作者：
Zhang H;Rola M;West JT;Tully DC;Kubis P;He J;Kankasa C;Wood C
了解能够在 HIV-1 围产期传播期间建立感染的病毒的特性对于设计限制传播的有效方法至关重要。我们之前证明，新传播的病毒（在婴儿中）比其相应母亲中的病毒更适合生长，这是由它们的包膜糖蛋白赋予的。在这里，我们进一步表征了来自六个母婴传播对的病毒包膜糖蛋白，并确定是否有任何特定的包膜功能与 HIV-1 C 亚型围产期传播相关。我们发现，与同时代的母体病毒相比，大多数新传播的病毒更不易被母体血浆中和。然而，新传播的变异体对混合异源血浆的中和反应敏感，但总体上对 IgG1 b12 具有抗性。包膜处理和掺入效率都不能预测病毒的传播能力。这些发现进一步了解了围产期传播的 HIV-1 的特征，并可能对干预方法产生影响。
Understanding the properties of viruses capable of establishing infection during perinatal transmission of HIV-1 is critical for designing effective means of limiting transmission. We previously demonstrated that the newly transmitted viruses (in infant) were more fit in growth, as imparted by their envelope glycoproteins, than those in their corresponding mothers. Here, we further characterized the viral envelope glycoproteins from six mother-infant transmission pairs and determined whether any specific envelope functions correlate with HIV-1 subtype C perinatal transmission. We found that most newly transmitted viruses were less susceptible to neutralization by their maternal plasma compared to contemporaneous maternal viruses. However, the newly transmitted variants were sensitive to neutralization by pooled heterologous plasma but in general were resistant to IgG1 b12. Neither Env processing nor incorporation efficiency was predictive of viral transmissibility. These findings provide further insight into the characteristics of perinatally transmissible HIV-1 and may have implications for intervention approaches.
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