VITAL-Bone Health: rationale and design of two ancillary studies evaluating the effects of vitamin D and/or omega-3 fatty acid supplements on incident fractures and bone health outcomes in the VITamin D and OmegA-3 TriaL (VITAL).
VITAL-Bone Health: rationale and design of two ancillary studies evaluating the effects of vitamin D and/or omega-3 fatty acid supplements on incident fractures and bone health outcomes in the VITamin D and OmegA-3 TriaL (VITAL).
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DOI：
10.1016/j.cct.2015.01.007
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发表时间：
2015-03
影响因子：
2.2
通讯作者：
Manson JE
中科院分区：
文献类型：
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作者：
LeBoff MS;Yue AY;Copeland T;Cook NR;Buring JE;Manson JE
虽然维生素D被广泛用于促进骨骼健康，但缺乏关于补充维生素D对骨骼的益处和风险的明确数据。在普通人群中进行的大型随机对照试验的结果很稀少。补充omega-3脂肪酸(FAs)对骨骼的影响的数据也有限。维生素D和omega-3试验(VITAL)是一项双盲安慰剂对照试验，评估维生素D3(2000IU/d)和omega-3FA(1g/d)补充剂在降低美国≥50岁男性和≥55岁女性癌症和心血管疾病风险方面的作用。为了全面测试补充维生素D和/或omega-3脂肪酸对骨骼健康的影响，VITAL：对骨折的影响辅助研究正在确定这些补充剂对参加父母试验的25,875名参与者发生骨折的影响。研究人员通过详细审查医疗记录和放射图像(髋部和股骨)来判定骨折。在一项补充的辅助、至关重要的：对结构和架构的影响中，正在通过面对面访问期间的详细表型来确定补充维生素D和/或omega-3脂肪酸对骨骼的影响。对骨密度、周转率、结构/结构、身体成分和体能的全面评估在基线和随机化两年后进行。这些研究的结果将澄清补充维生素D和/或omega-3脂肪酸对骨骼健康结果的关系，并为临床护理和公共卫生指南提供关于使用补充维生素D对女性和男性骨折进行一级预防的信息。
Although vitamin D is widely used to promote skeletal health, definitive data on benefits and risks of supplemental vitamin D alone on bone are lacking. Results from large, randomized controlled trials in the general population are sparse. Data on the effects of supplemental omega-3 fatty acids (FAs) on bone are also limited. The VITamin D and OmegA-3 TriaL (VITAL) is a double-blind, placebo-controlled trial assessing the role of vitamin D3 (2000 IU/d) and omega-3 FA (1 g/d) supplements in reducing risks of cancer and cardiovascular disease among U.S. men aged ≥50 and women aged ≥55. To comprehensively test effects of supplemental vitamin D and/or omega-3 FAs on skeletal health, the VITAL: Effects on Fractures ancillary study is determining the effects of these supplements on incident fractures among 25,875 participants enrolled in the parent trial. Study investigators adjudicate fractures through detailed review of medical records and radiological images (hip and femur). In a complementary ancillary, VITAL: Effects on Structure and Architecture is determining the effects of supplemental vitamin D and/or omega-3 FAs on bone with detailed phenotyping during in-person visits. Comprehensive assessments of bone density, turnover, structure/architecture, body composition, and physical performance are being performed at baseline and 2 years post-randomization. Results from these studies will clarify the relationship between supplemental vitamin D and/or omega-3 FAs on bone health outcomes, and inform clinical care and public health guidelines on the use of supplemental vitamin D for the primary prevention of fractures in women and men.
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影响因子：
4.2
作者：
Farina, Emily K.;Kiel, Douglas P.;Tucker, Katherine L.
通讯作者：
Tucker, Katherine L.
影响因子：
6.2
作者：
Burge, Russel;Dawson-Hughes, Bess;Tosteson, Anna
通讯作者：
Tosteson, Anna
影响因子：
5.8
作者：
BRENT, GA;LEBOFF, MS;BROWN, EM
通讯作者：
BROWN, EM
同时性维生素D和性激素缺乏症与老年男性骨质流失和骨折风险的关联：男性骨质疏松性骨折（MROS）研究。
影响因子：
6.2
作者：
Barrett-Connor, Elizabeth;Laughlin, Gail A.;Li, Hong;Nielson, Carrie M.;Wang, P. Ying;Dam, Tien T.;Cauley, Jane A.;Ensrud, Kristine E.;Stefanick, Marcia L.;Lau, Edith;Hoffman, Andrew R.;Orwoll, Eric S.
通讯作者：
Orwoll, Eric S.
影响因子：
19.6
作者：
通讯作者：
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