Blood flow and cell-free layer in microvessels.
Blood flow and cell-free layer in microvessels.
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DOI：
10.1111/j.1549-8719.2010.00056.x
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Karniadakis GE
中科院分区：
文献类型：
--
作者：
Fedosov DA;Caswell B;Popel AS;Karniadakis GE
采用耗散粒子动力学方法，将血液建模为红细胞悬浮液。红细胞膜是粗粒度的，用于有效模拟多个细胞，但准确地描述了其粘弹性。本文对直径为10 ~ 40 μm的微型管中的血液流动进行了三维数值模拟，血细胞比容值在0.15-0.45之间，并与已有的实验数据进行了比较。不同血细胞比容值的速度曲线显示钝度随着血细胞比容的增加而增加。红细胞质心分布表明细胞从管壁迁移到管中心。这导致在管壁旁边形成无细胞层，对应于实验观察到的Fahraeus和Fahraeus-Lindqvist效应。预测的无细胞层宽度与体外实验中发现的一致;结果也与体内实验定性一致。然而，为了模拟微血管流动，必须考虑额外的特征，例如，内皮糖萼。所开发的模型是能够捕获血流特性，并提供了一个计算框架，在介观水平上获得现实的预测正常和病理条件下的微循环中的血流。
Blood is modeled as a suspension of red blood cells using the dissipative particle dynamics method. The red blood cell membrane is coarse-grained for efficient simulations of multiple cells, yet accurately describes its viscoelastic properties. Blood flow in microtubes ranging from 10 to 40 μm in diameter is simulated in three dimensions for values of hematocrit in the range of 0.15–0.45 and carefully compared with available experimental data. Velocity profiles for different hematocrit values show an increase in bluntness with an increase in hematocrit. Red blood cell center-of-mass distributions demonstrate cell migration away from the wall to the tube center. This results in the formation of a cell-free layer next to the tube wall corresponding to the experimentally observed Fahraeus and Fahraeus–Lindqvist effects. The predicted cell-free layer widths are in agreement with those found in in vitro experiments; the results are also in qualitative agreement with in vivo experiments. However, additional features have to be taken into account for simulating microvascular flow, e.g., the endothelial glycocalyx. The developed model is able to capture blood flow properties and provides a computational framework at the mesoscopic level for obtaining realistic predictions of blood flow in microcirculation under normal and pathological conditions.
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DOI：
10.1016/j.msec.2005.08.020
发表时间：
2006-09-01
期刊：
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/j.cma.2010.02.001
发表时间：
2010-06-01
影响因子：
7.2
作者：
Fedosov DA;Caswell B;Karniadakis GE
通讯作者：
Karniadakis GE
DOI：
10.1073/pnas.0811484106
发表时间：
2009-04-14
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
20.1
作者：
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GAEHTGENS, P