Magnetic hyperthermia with ε-Fe(2)O(3) nanoparticles.
Magnetic hyperthermia with ε-Fe(2)O(3) nanoparticles.
复制标题
带有ε-FE的磁性高温（2）O（3）纳米颗粒。
作者：
由于生物相容性的限制，磁性纳米粒子在磁热治疗中的应用仅限于铁氧化物，即磁铁矿(Fe3O4)和磁铁矿(γ-Fe2O3)。然而，还有一种磁性氧化铁相迄今为止还没有被考虑过，尽管它具有独特的磁性：ε-Fe_2O_3。事实上，尽管Fe3O4和γ-Fe2O_3具有相对较低的磁矫顽力，但ε-Fe_2O_3表现出巨大的矫顽力。在本报告中，测量了ε-Fe_2O_3纳米粒子与尺寸相似的γ-Fe_2O_3纳米粒子(∼20 nm)在宽范围的场频和振幅下的加热功率，在未涂层和聚合物涂层的样品中。研究发现，ε-Fe_2O_3纳米粒子主要在黏度与细胞质相近的介质中进行低频加热(20-100 kHz)。相反，γ-Fe_2O_3纳米颗粒在高频范围(400-900千赫)加热更有效。细胞培养实验表明，在较宽的纳米颗粒浓度范围内没有毒性，内化率很高。总之，在人体热疗应用中，ε-Fe_2O_3纳米粒子的性能略逊于γ-Fe_2O_3纳米粒子。然而，这些ε-Fe_2O_3纳米粒子由于其对频率的独特响应而为可切换磁加热开辟了道路。ε-Fe_2O_3是一种具有巨大矫直力的磁性氧化铁。通过与γ-Fe_2O_3在很宽的场频和场幅范围内的比较，对其在热疗应用中的潜力进行了评估。
Biocompatibility restrictions have limited the use of magnetic nanoparticles for magnetic hyperthermia therapy to iron oxides, namely magnetite (Fe3O4) and maghemite (γ-Fe2O3). However, there is yet another magnetic iron oxide phase that has not been considered so far, in spite of its unique magnetic properties: ε-Fe2O3. Indeed, whereas Fe3O4 and γ-Fe2O3 have a relatively low magnetic coercivity, ε-Fe2O3 exhibits a giant coercivity. In this report, the heating power of ε-Fe2O3 nanoparticles in comparison with γ-Fe2O3 nanoparticles of similar size (∼20 nm) was measured in a wide range of field frequencies and amplitudes, in uncoated and polymer-coated samples. It was found that ε-Fe2O3 nanoparticles primarily heat in the low-frequency regime (20–100 kHz) in media whose viscosity is similar to that of cell cytoplasm. In contrast, γ-Fe2O3 nanoparticles heat more effectively in the high frequency range (400–900 kHz). Cell culture experiments exhibited no toxicity in a wide range of nanoparticle concentrations and a high internalization rate. In conclusion, the performance of ε-Fe2O3 nanoparticles is slightly inferior to that of γ-Fe2O3 nanoparticles in human magnetic hyperthermia applications. However, these ε-Fe2O3 nanoparticles open the way for switchable magnetic heating owing to their distinct response to frequency. ε-Fe2O3 is a magnetic iron(iii) oxide with a giant coercivity. Its potential in hyperthermia applications has been evaluated in comparison with γ-Fe2O3 over a wide range of field frequencies and amplitudes.
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DOI：
10.1083/jcb.112.4.719
发表时间：
1991-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fushimi K;Verkman AS
通讯作者：
Verkman AS
影响因子：
--
作者：
BROWN, WF
通讯作者：
BROWN, WF
影响因子：
3.2
作者：
Ali, Lamiaa M. A.;Pinol, Rafael;Sorribas, Victor
通讯作者：
Sorribas, Victor
影响因子：
2.7
作者：
Dutz, Silvio;Clement, Joachim H.;Zeisberger, Matthias
通讯作者：
Zeisberger, Matthias
振荡磁性纳米颗粒在杀死肿瘤细胞中的形态学作用。
影响因子：
--
作者：
Cheng D;Li X;Zhang G;Shi H
通讯作者：
Shi H