Visual behaviour mediated by retinal projections directed to the auditory pathway
Visual behaviour mediated by retinal projections directed to the auditory pathway
复制标题
由视网膜投射介导的视觉行为引导至听觉通路
作者：
Laurie von Melchner;S. Pallas;M. Sur
皮质发育中一个未解决的问题涉及内在和外在因素对不同皮质区域功能规范的相对贡献。雪貂的视网膜投射在新生儿期被重定向到听觉丘脑，在听觉丘脑和皮层中具有视觉反应细胞，在听觉皮层中形成视网膜专题图，并且在听觉皮层中具有视觉皮层细胞典型的视觉感受野特性。在这里，我们报告这种跨模式投射及其在听觉皮层中的表征可以调节视觉行为。当光刺激出现在仅通过这种投影“看到”的视野部分时，“重新连接”的雪貂会做出反应，就好像它们感知到的是视觉刺激而不是听觉刺激一样。因此，新皮质区域的知觉形态在很大程度上是由其外在输入指示的。此外，尽管光栅敏锐度低于正常视觉通路，但重新布线通路可以区分不同空间频率的光栅。
An unresolved issue in cortical development concerns the relative contributions of intrinsic and extrinsic factors to the functional specification of different cortical areas. Ferrets in which retinal projections are redirected neonatally to the auditory thalamus have visually responsive cells in auditory thalamus and cortex, form a retinotopic map in auditory cortex and have visual receptive field properties in auditory cortex that are typical of cells in visual cortex. Here we report that this cross-modal projection and its representation in auditory cortex can mediate visual behaviour. When light stimuli are presented in the portion of the visual field that is ‘seen’ only by this projection, ‘rewired’ ferrets respond as though they perceive the stimuli to be visual rather than auditory. Thus the perceptual modality of a neocortical region is instructed to a significant extent by its extrinsic inputs. In addition, gratings of different spatial frequencies can be discriminated by the rewired pathway, although the grating acuity is lower than that of the normal visual pathway.
影响因子：
33.6
作者：
通讯作者：
--
影响因子：
56.9
作者：
SUR, M;GARRAGHTY, PE;ROE, AW
通讯作者：
ROE, AW
影响因子：
56.9
作者：
RAKIC, P
通讯作者：
RAKIC, P