GLP-1 and energy balance: an integrated model of short-term and long-term control.
GLP-1 and energy balance: an integrated model of short-term and long-term control.
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DOI：
10.1038/nrendo.2011.77
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发表时间：
2011-06-07
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--
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胰高血糖素样肽1(GLP-1)是一种由肠道分泌的多肽，对营养物质的摄取有反应，它最为人所知的可能是它对葡萄糖刺激的胰岛素分泌的影响。GLP-1也由尾侧脑干中的神经元分泌，在啮齿类动物中，中枢应用GLP-1可以有效地减少食物摄入量。在过去的十年中，GLP-1不仅成为调节血糖水平的系统的重要组成部分，而且也成为治疗2型糖尿病的一个可行的治疗靶点。然而，尽管已知GLP-1受体激动剂可以在糖尿病患者中产生适度但统计上显著的体重减轻，但我们对内源性GLP-1如何调节食物摄入量和体重的了解仍然有限。这篇综述的目的是讨论我们对内源性GLP-1如何调节能量平衡的理解的演变。具体地说，我们考虑了中枢和外周GLP-1的贡献，并提出了一个短期和长期能量平衡控制的综合模型。最后，我们针对目前基于GLP-1的治疗方法讨论了这一模型，并建议正在进行的研究，以最大限度地提高基于GLP-1的肥胖治疗的有效性。
Glucagon-like peptide 1 (GLP-1), a peptide secreted from the intestine in response to nutrient ingestion, is perhaps best known for its effect on glucose-stimulated insulin secretion. GLP-1 is also secreted from neurons in the caudal brainstem, and it is well-established that, in rodents, central administration of GLP-1 potently reduces food intake. Over the past decade, GLP-1 has emerged not only as an essential component of the system that regulates blood glucose levels but also as a viable therapeutic target for the treatment of type 2 diabetes mellitus. However, although GLP-1 receptor agonists are known to produce modest but statistically significant weight loss in patients with diabetes mellitus, our knowledge of how endogenous GLP-1 regulates food intake and body weight remains limited. The purpose of this Review is to discuss the evolution of our understanding of how endogenous GLP-1 modulates energy balance. Specifically, we consider contributions of both central and peripheral GLP-1 and propose an integrated model of short-term and long-term control of energy balance. Finally, we discuss this model with respect to current GLP-1-based therapies and suggest ongoing research in order to maximize the effectiveness of GLP-1-based treatment of obesity.
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