The role of 5-hydroxymethylcytosine in human cancer.
The role of 5-hydroxymethylcytosine in human cancer.
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DOI：
10.1007/s00441-014-1896-7
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发表时间：
2014-06
影响因子：
3.6
通讯作者：
Jin, Seung-Gi
中科院分区：
文献类型：
--
作者：
Pfeifer, Gerd P.;Xiong, Wenying;Hahn, Maria A.;Jin, Seung-Gi
人类癌细胞中的DNA甲基化模式是高度异常的，并且通常涉及在正常组织中通常未甲基化的数百或数千个CpG岛处获得DNA超甲基化。最近发现的5-羟甲基胞嘧啶（5 hmC）作为5-甲基胞嘧啶（5 mC）的酶促氧化产物，导致模型和实验数据，其中超甲基化和5 mC氧化途径可能成为连接。这一背景下的关键发现包括，编码参与5 mC氧化反应的蛋白质的几个基因在人类肿瘤中发生突变，并且在许多类型的癌症中存在5 hmC的广泛丢失。在这篇综述中，我们将总结目前的知识，并讨论模型的潜在作用，5 hmC在人类癌症生物学。
The patterns of DNA methylation in human cancer cells are highly abnormal and often involve the acquisition of DNA hypermethylation at hundreds or thousands of CpG islands that are usually unmethylated in normal tissues. The recent discovery of 5-hydroxymethylcytosine (5hmC) as an enzymatic oxidation product of 5-methylcytosine (5mC) has led to models and experimental data in which the hypermethylation and 5mC oxidation pathways may become connected. Key discoveries in this setting include the findings that several genes coding for proteins involved in the 5mC oxidation reaction are mutated in human tumors and that there is a broad loss of 5hmC across many types of cancer. In this review, we will summarize current knowledge and discuss models of the potential roles of 5hmC in human cancer biology.
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DOI：
10.1126/science.1229277
发表时间：
2013-01-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hackett JA;Sengupta R;Zylicz JJ;Murakami K;Lee C;Down TA;Surani MA
通讯作者：
Surani MA
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
50.3
作者：
Figueroa ME;Abdel-Wahab O;Lu C;Ward PS;Patel J;Shih A;Li Y;Bhagwat N;Vasanthakumar A;Fernandez HF;Tallman MS;Sun Z;Wolniak K;Peeters JK;Liu W;Choe SE;Fantin VR;Paietta E;Löwenberg B;Licht JD;Godley LA;Delwel R;Valk PJ;Thompson CB;Levine RL;Melnick A
通讯作者：
Melnick A
影响因子：
3.7
作者：
Globisch D;Münzel M;Müller M;Michalakis S;Wagner M;Koch S;Brückl T;Biel M;Carell T
通讯作者：
Carell T
影响因子：
3.5
作者：
Castro-Vega, Luis Jaime;Buffet, Alexandre;Gimenez-Roqueplo, Anne-Paule
通讯作者：
Gimenez-Roqueplo, Anne-Paule