Structurally plastic peptide capsules for synthetic antimicrobial viruses.
Structurally plastic peptide capsules for synthetic antimicrobial viruses.
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DOI：
10.1039/c5sc03260a
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发表时间：
2016-03-01
期刊：
影响因子：
8.4
通讯作者：
Ryadnov MG
中科院分区：
文献类型：
--
作者：
Castelletto V;de Santis E;Alkassem H;Lamarre B;Noble JE;Ray S;Bella A;Burns JR;Hoogenboom BW;Ryadnov MG
A conceptual design for artificial antimicrobial viruses is described. A conceptual design for artificial antimicrobial viruses is described. The design emulates viral assembly and function to create self-assembling peptide capsules that promote efficient gene delivery and silencing in mammalian cells. Unlike viruses, however, the capsules are antimicrobial, which allows them to exhibit a dual biological function: gene transport and antimicrobial activity. Unlike other antimicrobials, the capsules act as pre-concentrated antimicrobial agents that elicit rapid and localised membrane-disrupting responses by converting into individual pores at their precise landing positions on membranes. The concept holds promise for engineering virus-like scaffolds with biologically tuneable properties.
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