Behavioral, neurobiological, and neurochemical mechanisms of ethanol self-administration: A translational review.
Behavioral, neurobiological, and neurochemical mechanisms of ethanol self-administration: A translational review.
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DOI：
10.1016/j.pharmthera.2020.107573
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发表时间：
2020-08
影响因子：
13.5
通讯作者：
Gonzales RA
中科院分区：
文献类型：
--
作者：
Vena AA;Zandy SL;Cofresí RU;Gonzales RA
Alcohol use disorder has multiple characteristics including excessive ethanol consumption, impaired control over drinking behaviors, craving and withdrawal symptoms, compulsive seeking behaviors, and is considered a chronic condition. Relapse is common. Determining the neurobiological targets of ethanol and the adaptations induced by chronic ethanol exposure is critical to understanding the clinical manifestation of alcohol use disorders, the mechanisms underlying the various features of the disorder, and for informing medication development. In the present review, we discuss ethanol’s interactions with a variety of neurotransmitter systems, summarizing findings from preclinical and translational studies to highlight recent progress in the field. We then describe animal models of ethanol self-administration, emphasizing the value, limitations, and validity of commonly used models. Lastly, we summarize the behavioral changes induced by chronic ethanol self-administration, with an emphasis on cue-elicited behavior, the role of ethanol-related memories, and the emergence of habitual ethanol seeking behavior.
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DOI：
10.1016/j.pbb.2011.07.017
发表时间：
2011-11
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Bell RL;Rodd ZA;Smith RJ;Toalston JE;Franklin KM;McBride WJ
通讯作者：
McBride WJ
影响因子：
--
作者：
Alongkronrusmee, Doungkamol;Chiang, Terrance;van Rijn, Richard M
通讯作者：
van Rijn, Richard M
DOI：
10.1080/14640748108400816
发表时间：
1981-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ADAMS, CD;DICKINSON, A
通讯作者：
DICKINSON, A
影响因子：
3.4
作者：
BALDWIN, HA;RASSNICK, S;BRITTON, KT
通讯作者：
BRITTON, KT
影响因子：
5.3
作者：
Alfonso-Loeches, Silvia;Pascual-Lucas, Maya;Guerri, Consuelo
通讯作者：
Guerri, Consuelo