Modeling binge-like ethanol drinking by peri-adolescent and adult P rats.
Modeling binge-like ethanol drinking by peri-adolescent and adult P rats.
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DOI：
10.1016/j.pbb.2011.07.017
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
McBride WJ
中科院分区：
文献类型：
--
作者：
Bell RL;Rodd ZA;Smith RJ;Toalston JE;Franklin KM;McBride WJ
酗酒，特别是青少年和年轻人的酗酒，是一个严重的公共卫生问题。本研究采用我们实验室使用的黑暗中多次预定存取（DID-MSA）程序，检查了围青春期[出生后30-72天（PND 30-72）]和成年（PND 90-132）酒精偏好（P）大鼠的酒精狂欢样饮酒。雄性和雌性P大鼠同时获得15%和30%乙醇，在黑暗周期中持续3个1小时，每周5天。对于第1周，青春期和成年雌性P大鼠消耗的乙醇分别为3.4和1.6 g/kg，在第1小时的访问，而雄性大鼠的值分别为3.5和1.1 g/kg的乙醇，分别。在6周乙醇使用期间，成人摄入量增加至约2.0 g/kg/hr，青少年摄入量降低至约2.5 g/kg/hr。成年DID-MSA大鼠的每日乙醇摄入量接近或略微超过连续接入（CA）大鼠或P大鼠的选择标准（≥ 5 g/kg/天）。然而，在一般情况下，每日乙醇摄入量的DID-MSA围青春期大鼠显着超过他们的CA同行。在第4周期间，每隔15分钟评估一次BELs，时间跨度为进入的第3小时。在15分钟和60分钟时，乙醇摄入量分别为1.7 g/kg和2.7 g/kg，BEL分别为57 mg%和100 mg%。在第1周和第4周的乙醇接触期间，评估了雌性P大鼠中由DID-MSA诱导的中毒。两周之间的损伤水平没有差异（106与97秒的跌倒潜伏期，120秒标准），仅在第4周期间具有显著性（与未处理对照组相比）。总的来说，这些研究结果支持使用的DID-MSA程序在大鼠中，并强调存在的年龄和性别依赖性的影响，介导的乙醇狂欢样饮酒在P大鼠。
Alcohol binge-drinking, especially among adolescents and young adults, is a serious public health concern. The present study examined ethanol binge-like drinking by peri-adolescent [postnatal days (PNDs 30—72)] and adult (PNDs 90—132) alcohol-preferring (P) rats with a drinking-in-the-dark—multiple-scheduled-acces (DID-MSA) procedure used by our laboratory. Male and female P rats were provided concurrent access to 15% and 30% ethanol for three 1-hr sessions across the dark cycle 5 days/week. For the 1st week, adolescent and adult female P rats consumed 3.4 and 1.6 g/kg of ethanol, respectively, during the 1st hr of access, whereas for male rats the values were 3.5 and 1.1 g/kg of ethanol, respectively. Adult intakes increased to ~2.0 g/kg/hr and adolescent intakes decreased to ~2.5 g/kg/hr across the 6 weeks of ethanol access. The daily ethanol intake of adult DID-MSA rats approximated or modestly exceeded that seen in continuous access (CA) rats or the selection criterion for P rats (≥ 5g/kg/day). However, in general, the daily ethanol intake of DID-MSA peri-adolescent rats significantly exceeded that of their CA counterparts. BELs were assessed at 15-min intervals across the 3rd hr of access during the 4th week. Ethanol intake was 1.7 g/kg vs. 2.7 g/kg and BELs were 57 mg% vs. 100 mg% at 15- and 60-min, respectively. Intoxication induced by DID-MSA in female P rats was assessed during the 1st vs. 4th week of ethanol access. Level of impairment did not differ between the 2 weeks (106 vs. 97 sec latency to fall, 120 sec criterion) and was significant (vs. naïve controls) only during the 4th week. Overall, these findings support the use of the DID-MSA procedure in rats, and underscore the presence of age- and sex-dependent effects mediating ethanol binge-like drinking in P rats.
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影响因子：
2.3
作者：
Bell, RL;Rodd, ZA;McBride, WJ
通讯作者：
McBride, WJ
DOI：
10.1097/01.alc.0000183007.65998.aa
发表时间：
2005-10-01
影响因子：
3.2
作者：
Doremus, TL;Brunell, SC;Spear, LP
通讯作者：
Spear, LP
影响因子：
2.8
作者：
Adams, Michael;Effertz, Tobias
通讯作者：
Effertz, Tobias
影响因子：
3.7
作者：
Chamberlain, E.;Solomon, R.
通讯作者：
Solomon, R.
影响因子：
2.3
作者：
ADAMS, N
通讯作者：
ADAMS, N