Prognostic value of triglyceride glucose (TyG) index in patients with acute decompensated heart failure.
Prognostic value of triglyceride glucose (TyG) index in patients with acute decompensated heart failure.
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甘油三酯葡萄糖（TyG）指数对急性失代偿性心力衰竭患者的预后价值
DOI：
10.1186/s12933-022-01507-7
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发表时间：
2022-05-31
影响因子：
9.3
通讯作者：
中科院分区：
文献类型：
--
作者：
背景甘油三酯葡萄糖（TyG）指数已被认为是胰岛素抵抗（IR）的可靠指标和心血管疾病风险的独立预测因子。然而，其在急性失代偿性心力衰竭（ADHF）患者的预后价值仍不清楚。方法共932例ADHF住院患者从2018年1月1日至2021年2月1日纳入这项回顾性研究。TyG指数计算为ln [空腹甘油三酯水平（mg/dL）×空腹血糖水平（mg/dL）/2]。根据TyG指数值将患者分为三分位数。主要终点为随访期间的全因死亡、心血管（CV）死亡和主要不良心脑事件（MACCE）。我们采用多变量调整后的考克斯比例风险模型和限制性三次样条分析，以探讨与主要endpoints.ResultsDuring的中位随访时间为478天，全因死亡，CV死亡和MACCE发生在140（15.0%），103（11.1%）和443（47.9%）例，分别。在多变量考克斯比例风险模型中，事件主要终点的风险与最高TyG三分位数相关。调整混杂因素后，最高三分位数的风险比（HR）（TyG指数≥ 9.32）与最低三分位数（TyG指数< 8.83）为2.09（95%置信区间[CI]，1.23-3.55; p = 0.006）全因死亡，2.31（95% CI，1.26-4.24; p = 0.007），MACE为1.83（95% CI，1.18-3.01; p = 0.006）。限制性三次样条分析还显示，主要终点的累积风险随着TyG指数的增加而增加。当TyG指数被用作连续变量时，三个主要终点的风险比在TyG指数的较高范围内迅速增加（全因死亡，TyG > 9.08; CV死亡，TyG > 9.46; MACCE，TyG > 9.87）。
BackgroundThe triglyceride glucose (TyG) index has been proposed as a reliable marker of insulin resistance (IR) and an independent predictor of cardiovascular disease risk. However, its prognostic value in patients with acute decompensated heart failure (ADHF) remains unclear.MethodsA total of 932 hospitalized patients with ADHF from January 1st, 2018 to February 1st, 2021 were included in this retrospective study. The TyG index was calculated as ln [fasting triglyceride level (mg/dL) × fasting plasma glucose level (mg/dL)/2]. Patients were divided into tertiles according to TyG index values. The primary endpoints were all-cause death, cardiovascular (CV) death and major adverse cardiac and cerebral events (MACCEs) during follow-up. We used multivariate adjusted Cox proportional hazard models and restricted cubic spline analysis to investigate the associations of the TyG index with primary endpoints.ResultsDuring a median follow-up time of 478 days, all-cause death, CV death and MACCEs occurred in 140 (15.0%), 103 (11.1%) and 443 (47.9%) cases, respectively. In multivariate Cox proportional hazard models, the risk of incident primary endpoints was associated with the highest TyG tertile. After adjustment for confounding factors, hazard ratios (HRs) for the highest tertile (TyG index ≥ 9.32) versus the lowest tertile (TyG index < 8.83) were 2.09 (95% confidence interval [CI], 1.23–3.55; p = 0.006) for all-cause death, 2.31 (95% CI, 1.26–4.24; p = 0.007) for CV death and 1.83 (95% CI, 1.18–3.01; p = 0.006) for MACCEs. Restricted cubic spline analysis also showed that the cumulative risk of primary endpoints increased as TyG index increased. When the TyG index was used as a continuous variable, the hazard ratios of the three primary endpoints rapidly increased within the higher range of the TyG index (all cause death, TyG > 9.08; CV death, TyG > 9.46; MACCEs, TyG > 9.87).ConclusionsThe elevated TyG index was independently associated with poor prognosis, and thus would be useful in the risk stratification in patients with ADHF.
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DOI：
10.1016/j.arth.2021.06.002
发表时间：
2021-10
期刊：
The Journal of arthroplasty
影响因子：
--
作者：
Lundgreen CS;Larson DR;Atkinson EJ;Devick KL;Lewallen DG;Berry DJ;Maradit Kremers H;Crowson CS
通讯作者：
Crowson CS
影响因子：
9.3
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Lin SJ
影响因子：
9.3
作者：
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通讯作者：
Zhao, Yingxin
影响因子：
5.1
作者：
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DOI：
10.1038/s41572-020-0151-7
发表时间：
2020-03-05
期刊：
Nature reviews. Disease primers
影响因子：
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作者：
Arrigo M;Jessup M;Mullens W;Reza N;Shah AM;Sliwa K;Mebazaa A
通讯作者：
Mebazaa A