Formulations for Bacteriophage Therapy and the Potential Uses of Immobilization.
Formulations for Bacteriophage Therapy and the Potential Uses of Immobilization.
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DOI：
10.3390/ph14040359
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发表时间：
2021-04-13
期刊：
影响因子：
--
通讯作者：
Clark J
中科院分区：
文献类型：
--
作者：
Rosner D;Clark J
抗药性病原体的出现在细菌性疾病的治疗中变得越来越成问题。这导致噬菌体作为一种替代治疗形式受到越来越多的关注。噬菌体在靶向和杀死感兴趣的细菌菌株方面是有效的，并且当作为针对重症患者的定制治疗的一部分作为最后手段施用时，已经产生了令人鼓舞的结果。尽管如此，临床试验的成功并不总是那么快，几项备受瞩目的试验未能证明噬菌体制剂在治疗感兴趣的疾病方面的功效。虽然这可能部分是由于噬菌体选择性差和缺乏对潜在疾病的了解的原因，但越来越多的共识是，临床试验的未来成功将取决于噬菌体治疗剂有效地递送到感染区域。这可以使用噬菌体制剂而不是纯液体制剂来实现。几种基于消除的策略可以应用于产生噬菌体制剂，并且在功效以及长期噬菌体稳定性方面已经观察到令人鼓舞的结果。基于固定化的方法通常被忽视用于生产噬菌体治疗剂，但也可以提供可行的替代方案。
The emergence of antibiotic-resistant pathogens is becoming increasingly problematic in the treatment of bacterial diseases. This has led to bacteriophages receiving increased attention as an alternative form of treatment. Phages are effective at targeting and killing bacterial strains of interest and have yielded encouraging results when administered as part of a tailored treatment to severely ill patients as a last resort. Despite this, success in clinical trials has not always been as forthcoming, with several high-profile trials failing to demonstrate the efficacy of phage preparations in curing diseases of interest. Whilst this may be in part due to reasons surrounding poor phage selection and a lack of understanding of the underlying disease, there is growing consensus that future success in clinical trials will depend on effective delivery of phage therapeutics to the area of infection. This can be achieved using bacteriophage formulations instead of purely liquid preparations. Several encapsulation-based strategies can be applied to produce phage formulations and encouraging results have been observed with respect to efficacy as well as long term phage stability. Immobilization-based approaches have generally been neglected for the production of phage therapeutics but could also offer a viable alternative.
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DOI：
10.1016/j.ejpb.2017.09.002
发表时间：
2017-12
期刊：
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
影响因子：
--
作者：
Chang RY;Wong J;Mathai A;Morales S;Kutter E;Britton W;Li J;Chan HK
通讯作者：
Chan HK
影响因子：
5.4
作者：
Bulbake U;Doppalapudi S;Kommineni N;Khan W
通讯作者：
Khan W
影响因子：
1.3
作者：
Aminov, Rustam;Caplin, Jonathan;Wittmann, Johannes
通讯作者：
Wittmann, Johannes
影响因子：
4.9
作者：
Chang, Rachel Yoon Kyung;Chen, Ke;Chan, Hak-Kim
通讯作者：
Chan, Hak-Kim
影响因子：
5.4
作者：
BALES, RC;LI, SM;GERBA, CP
通讯作者：
GERBA, CP