Tissue Distribution, Pharmacokinetics, and Effect of Hematological and Biochemical Parameters of Acute Intravenous Administration of Silver Nanoparticles in Rats.
Tissue Distribution, Pharmacokinetics, and Effect of Hematological and Biochemical Parameters of Acute Intravenous Administration of Silver Nanoparticles in Rats.
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DOI：
10.3390/nano14010029
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发表时间：
2023-12-21
期刊：
影响因子：
--
通讯作者：
Ahmed H
中科院分区：
文献类型：
--
作者：
Salim EI;Abdel-Halim KY;El-Mahalawy ME;Badr HA;Ahmed H
银纳米粒子 (AgNP) 的广泛生物医学和商业应用增加了其对人类和环境的潜在暴露以及对人类健康的毒性。啮齿类动物吸入、气管内滴注和口服后，AgNPs 的生物分布和毒性已有详细记录；然而，对于静脉注射 (IV) 施用的 AgNP 的生物分布及其器官特异性病理生理学效应知之甚少。在这里，我们研究了 IV 给药后雄性大鼠中 AgNP 的药代动力学模式和组织分布。在AgNP给药10分钟、1小时、6小时、12小时、24小时和168小时后人道处死动物，并在酸消化后测量血液样本和各种组织中的银（Ag）含量。 AgNPs 很容易被吸收，并在 6 小时后分布到大多数器官中，主要是结肠、小肠、肾脏和心脏；然而，168 小时后，它们在脊髓中达到最高值。在除 10 分钟外的所有时间点，给予 AgNP 的动物中白细胞 (WBC) 均显着增加 (42-60%)。关于血小板，所有给予 AgNP 的动物的计数均降低了 7.8-39.2%，计数最低出现在给药后 168 小时。就淋巴细胞 (LYM) 而言，经 AgNP 处理的动物在给药后 10 分钟和 1 小时内的计数降低了 19.5-41%；然而，给药后 168 小时，动物的计数增加了 30.5%。 AgNP 治疗动物的平均红细胞血红蛋白 (MCH) 计数减少了 50-62%。 AgNP 处理的动物中天冬氨酸转氨酶 (AST)、尿素和肌酐的浓度增加。综上所述，结果表明，AgNP 的急性静脉注射会改变动物的代谢和血液学参数，并可能对人类造成健康风险。
The widespread biomedical and commercial applications of silver nanoparticles (AgNPs) have increased their potential for human and environmental exposure and toxicity to human health. The bio-distribution and toxicity of AgNPs in rodents following inhalation, intratracheal instillation, and oral ingestion are well documented; however, little is known about the bio-distribution of intravenously (IV)-administered AgNPs and their organ-specific pathophysiological effects. Here, we investigate the pharmacokinetic pattern and tissue distribution of AgNPs in male rats following IV administration. The animals were humanely sacrificed after 10 min, 1 h, 6 h, 12 h, 24 h, and 168 h of AgNP administration, and the silver (Ag) content was measured from blood samples and various tissues following acid digestion. The AgNPs were readily absorbed and subsequently distributed into most organs predominantly in the colon, small intestine, kidney, and heart after 6 h; however, they were the highest in the spinal cord after 168 h. White blood cells (WBCs) were significantly increased (42–60%) in AgNP-administered animals at all time points except 10 min. Regarding platelets, all AgNP-administered animals showed counts 7.8–39.2% lower, with the lowest count at 168 h post-administration. In the case of lymphocytes (LYMs), the AgNP-treated animals exhibited a count 19.5–41% lower at 10 min and 1 h post-administration; however, the animals at 168 h post-administration showed a count 30.5% more. The mean corpuscular hemoglobin (MCH) counts from the AgNP-treated animals were decreased by 50–62%. The concentrations of aspartate transaminase (AST), urea, and creatinine were increased in the AgNP-treated animals. Taken together, the results suggest that the acute IV administration of AgNPs alters metabolic and hematological parameters in animals and may pose a health risk to humans.
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影响因子：
3.3
作者：
Alsaleh, Nasser B.;Minarchick, Valerie C.;Brown, Jared M.
通讯作者：
Brown, Jared M.
影响因子：
5.8
作者：
Miranda, Renata Rank;Sampaio, Isabella;Zucolotto, Valtencir
通讯作者：
Zucolotto, Valtencir
影响因子：
5.1
作者：
Adeyemi, Oluyomi Stephen;Uloko, Rhoda Ananu;Otohinoyi, David Adeiza
通讯作者：
Otohinoyi, David Adeiza
DOI：
10.1007/bf01926506
发表时间：
1973-01-01
期刊：
EXPERIENTIA
影响因子：
--
作者：
CREASEY, M;MOFFAT, DB
通讯作者：
MOFFAT, DB
影响因子：
0.9
作者：
Przybylowski, P.;Koc-Zorawska, E.;Malyszko, J.
通讯作者：
Malyszko, J.