A methodological approach to assessing the health impact of environmental chemical mixtures: PCBs and hypertension in the National Health and Nutrition Examination Survey.
A methodological approach to assessing the health impact of environmental chemical mixtures: PCBs and hypertension in the National Health and Nutrition Examination Survey.
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DOI：
10.3390/ijerph8114220
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发表时间：
2011-11
影响因子：
--
通讯作者：
White P
中科院分区：
文献类型：
--
作者：
Yorita Christensen KL;White P
我们描述了一种方法来检查暴露于化学混合物和健康结果之间的关系，使用多氯联苯（PCBs）和高血压作为我们的案例研究。研究了1999-2004年全国健康与营养调查参与者血清多氯联苯与高血压的关系。首先，使用无条件多变量逻辑回归来估计优势比和相关的95%置信区间。接下来，评估PCB同系物之间的相关性和多重共线性，并进行聚类分析以确定相关同系物组。最后，构建一个加权和来表示每个同源基因与高血压风险的相对重要性。多氯联苯血清浓度因人口统计学特征而异，高血压患者的平均浓度较高。逻辑回归结果显示同族和类别的结果混合。进一步的分析确定了相关多氯联苯的分组。采用加权和方法平衡不同范围和效价，多氯联苯66、101、118、128和187与高血压风险增加显著相关。流行病学数据被用来展示一种评估复杂环境暴露与健康结果之间关系的方法。分析大量相关暴露的复杂性，其中每一种暴露可能具有不同的效力和范围，在高血压风险与多氯联苯暴露之间的关系的背景下得到解决。
We describe an approach to examine the association between exposure to chemical mixtures and a health outcome, using as our case study polychlorinated biphenyls (PCBs) and hypertension. The association between serum PCB and hypertension among participants in the 1999–2004 National Health and Nutrition Examination Survey was examined. First, unconditional multivariate logistic regression was used to estimate odds ratios and associated 95% confidence intervals. Next, correlation and multicollinearity among PCB congeners was evaluated, and clustering analyses performed to determine groups of related congeners. Finally, a weighted sum was constructed to represent the relative importance of each congener in relation to hypertension risk. PCB serum concentrations varied by demographic characteristics, and were on average higher among those with hypertension. Logistic regression results showed mixed findings by congener and class. Further analyses identified groupings of correlated PCBs. Using a weighted sum approach to equalize different ranges and potencies, PCBs 66, 101, 118, 128 and 187 were significantly associated with increased risk of hypertension. Epidemiologic data were used to demonstrate an approach to evaluating the association between a complex environmental exposure and health outcome. The complexity of analyzing a large number of related exposures, where each may have different potency and range, are addressed in the context of the association between hypertension risk and exposure to PCBs.
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影响因子：
8.3
作者：
Everett, Charles J.;Mainous, Arch G., III;Matheson, Eric M.
通讯作者：
Matheson, Eric M.
环境污染物和人类健康风险分析中的脂质调整。
影响因子：
10.4
作者：
Schisterman, EF;Whitcomb, BW;Louis, GMB;Louis, TA
通讯作者：
Louis, TA
影响因子：
4.9
作者：
Goncharov, Alexey;Bloom, Michael;Carpenter, David O.
通讯作者：
Carpenter, David O.
影响因子：
10.4
作者：
Glynn AW;Granath F;Aune M;Atuma S;Darnerud PO;Bjerselius R;Vainio H;Weiderpass E
通讯作者：
Weiderpass E
影响因子：
5.4
作者：
Gennings, Chris;Sabo, Roy;Carney, Ed
通讯作者：
Carney, Ed