The DREAM complex promotes gene body H2A.Z for target repression.
The DREAM complex promotes gene body H2A.Z for target repression.
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DOI：
10.1101/gad.255810.114
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发表时间：
2015-03-01
影响因子：
10.5
通讯作者：
Ahringer J
中科院分区：
文献类型：
--
作者：
Latorre I;Chesney MA;Garrigues JM;Stempor P;Appert A;Francesconi M;Strome S;Ahringer J
The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes. Latorre et al. show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, DREAM targets have reduced gene body HTZ-1/H2A.Z and increased expression. Consistent with a repressive role for gene body H2A.Z, many DREAM targets are up-regulated in htz-1/H2A.Z mutants. The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, DREAM targets have reduced gene body HTZ-1/H2A.Z and increased expression. Consistent with a repressive role for gene body H2A.Z, many DREAM targets are up-regulated in htz-1/H2A.Z mutants. Our results indicate that the DREAM complex facilitates high gene body HTZ-1/H2A.Z, which plays a role in target gene repression.
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影响因子：
11.8
作者：
Ceol, CJ;Horvitz, HR
通讯作者：
Horvitz, HR
影响因子：
5.3
作者：
DeBruhl, Heather;Wen, Hong;Lipsick, Joseph S.
通讯作者：
Lipsick, Joseph S.
影响因子：
12.3
作者：
Kudron M;Niu W;Lu Z;Wang G;Gerstein M;Snyder M;Reinke V
通讯作者：
Reinke V
DOI：
10.1242/dev.02490
发表时间：
2006-08-01
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Chi, Woo;Reinke, Valerie
通讯作者：
Reinke, Valerie
影响因子：
1.2
作者：
Dimova, Dessislava K.
通讯作者：
Dimova, Dessislava K.