Metabolism of senile amyloid precursor and amyloidogenesis. Age-related acceleration of apolipoprotein A-II clearance in the senescence accelerated mouse.
Metabolism of senile amyloid precursor and amyloidogenesis. Age-related acceleration of apolipoprotein A-II clearance in the senescence accelerated mouse.
复制标题
老年淀粉样蛋白前体的代谢和淀粉样蛋白生成。
DOI：
--
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发表时间：
1988
影响因子：
6
通讯作者：
T. Takeda
中科院分区：
文献类型：
--
作者：
H. Naiki;K. Higuchi;T. Yonezu;M. Hosokawa;T. Takeda
用125I-高密度脂蛋白(ApoA-II)纯化的125I-高密度脂蛋白(ApoA-II)，研究了衰老加速小鼠、易衰小鼠(SAM-P/1)和耐衰老小鼠(SAM-R/1)血清中老年淀粉样蛋白相关高密度脂蛋白(HDLApo A-II)的清除动力学。在SAM-R/1中，用从两个菌株纯化的~(125)I-高密度脂蛋白。在SAM-R/1中，载脂蛋白A-II的血清半衰期不随年龄增长而改变，与载脂蛋白A-I的血清半衰期基本相同。2月龄SAM-P/1的载脂蛋白A-I和载脂蛋白A-II的血清半衰期与SAM-R/1基本相同，但在6和12个月龄时，SAM-P/1的载脂蛋白A-II的血清半衰期显著降低，且小于载脂蛋白A-I的半衰期。这些与年龄相关的载脂蛋白A-II清除动力学变化被观察到，而不考虑高密度脂蛋白供体。作者还用125I-apo A-II重组的高密度脂蛋白检测了注射的apo A-II的组织分布，发现老年SAM-P/1的几个器官比年轻小鼠捕获了更多的125I放射性。这一证据有力地表明，与年龄相关的载脂蛋白A-II代谢环境的改变可能影响SAM-P/1中老年淀粉样蛋白的形成。
Serum clearance kinetics of murine senile amyloid-related high-density lipoprotein (HDL) apoprotein A-II (apo A-II) was examined in the senescence-accelerated mouse, prone (SAM-P/1) and resistant (SAM-R/1), with 125I-HDL purified from both strains. In SAM-R/1, with 125I-HDL purified from both strains. In SAM-R/1, the serum half-life of apo A-II was not altered with increasing age and was practically identical to that of apo A-I. In 2-month old SAM-P/1, the serum half-life of both apo A-I and apo A-II was generally the same as observed in SAM-R/1. However, at age 6 and 12 months, in SAM-P/1, the serum half-life of apo A-II decreased significantly and was less than that of apo A-I. These age-related changes in apo A-II clearance kinetics were observed regardless of the HDL donor. The authors also examined the tissue distribution of injected apo A-II, using 125I-apo A-II reconstituted HDL, and found that several organs trapped more 125I radioactivity in old SAM-P/1 than in young mice. This evidence strongly suggests that age-related changes in the metabolic environment of apo A-II might affect senile amyloidogenesis in SAM-P/1.
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非人灵长类动物（黑长尾猴）高密度脂蛋白和乳糜微粒中血清淀粉样蛋白 A (SSA) 的代谢。
DOI：
--
发表时间：
1983
期刊：
The American journal of pathology
影响因子：
--
作者：
Parks,JS;Rudel,LL
通讯作者：
Rudel,LL
DOI：
10.1172/jci110635
发表时间：
1982
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Solomon,A;Frangione,B;Franklin,EC
通讯作者：
Franklin,EC
家族性淀粉样多发性神经病（FAP）瑞典品种中淀粉样蛋白的前白蛋白性质。
DOI：
10.1016/0006-291x(81)90764-6
发表时间：
1981
影响因子：
3.1
作者：
Skinner,M;Cohen,AS
通讯作者：
Cohen,AS
影响因子：
158.5
作者：
GOLDSTEIN, JL;KITA, T;BROWN, MS
通讯作者：
BROWN, MS
影响因子：
15.9
作者：
HOFFMAN, JS;BENDITT, EP
通讯作者：
BENDITT, EP