Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast
Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast
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口服避孕药（OCP）的使用会增加正常人乳腺上皮细胞的增殖并降低雌激素受体含量
DOI：
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发表时间：
1991
影响因子：
6.4
通讯作者：
C. Potten
中科院分区：
文献类型：
--
作者：
Gerard Williams;E. Anderson;A. Howell;R. Watson;John Covne;S. Roberts;C. Potten
The effect of ingestion of oral contraceptives (OCP) on cell proliferation and oestrogen (ER) and progesterone receptor (PR) expression of the epithelial cells of the normal human breast was compared with findings in controls not taking OCPs. Histologically normal breast tissue was removed during operation for fibroadenoma or reduction mammoplasty in 216 women whose mean age was 28.1 ± 8.5 years (±SD range 14–53 years). During natural cycles the mean proportion of cells expressing ER was 3.94 ± 3.71 (% mean ±SD, range 0–20.8, n = 51), while of those expressing PR it was 12.1 ± 7.1% (range 3.0–36.1, n = 47). There was a significant decline in ER during the menstrual cycle [p = <0.001 by multiple linear regression (MLR)], but there was no significant change in the proportion which expressed PR. The mean proportion of proliferating cells (LI) was 2.50 ± 2.42 (range 0–11.5, n = 147). There was a significant increase of LI during the cycle (p = <0.001, MLR) and a significant inverse relationship between LI and ER (r = −0.29, p < 0.01). Use of the OCP significantly reduced the number of cells which expressed ER and increased the LI earlier in the cycle. No effect of OCP use on the number of PR+ cells was detectable. We conclude that significant changes in the proportions of ER+ and proliferating cells occur during natural menstrual cycles. These changes are perturbed by ingestion of OCPs, so that there is greater suppression of ER and a longer period of high proliferation during the menstrual cycle. These results may explain the relationship between OCP use and the possible risk of breast cancer.
影响因子：
3.8
作者：
Ion G;Akinsete JA;Hardman WE
通讯作者：
Hardman WE
影响因子：
5.8
作者：
LESSEY, BA;KILLAM, AP;MCCARTY, KS
通讯作者：
MCCARTY, KS