Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice offspring.
Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice offspring.
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DOI：
10.1186/1471-2407-10-81
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发表时间：
2010-03-06
期刊：
影响因子：
3.8
通讯作者：
Hardman WE
中科院分区：
文献类型：
--
作者：
Ion G;Akinsete JA;Hardman WE
母亲食用富含omega -6多不饱和脂肪（n-6 PUFA）的食物会增加患乳腺癌的风险，而食用富含鱼油中的omega -3多不饱和脂肪（n-3 PUFA）的食物会降低大鼠雌性后代患乳腺癌的风险。这项研究的目的是确定在母亲的饮食中使用菜籽油代替玉米油来增加n-3多聚脂肪酸和减少n-6多聚脂肪酸是否可以降低雌性后代患乳腺癌的风险。雌性SV 129小鼠分为两组，分别饲喂含有10% w/w玉米油（50% n-6 PUFA，对照饲料）和10% w/w菜籽油（20% n-6 PUFA, 10% n-3 PUFA，试验饲料）的饲料。喂食两周后，雌性小鼠与纯合子C3(1) TAg转基因小鼠交配。母鼠在整个怀孕和哺育后代的过程中都吃指定的食物。断奶后，所有雌性后代维持对照组饮食。与玉米油饲粮（CO/CO组）相比，菜籽油饲粮（CA/CO组）的后代在整个试验过程中出现肿瘤的乳腺数量显著减少。在130日龄时，CA/CO组每只小鼠的肿瘤数量显著减少（多样性）；肿瘤发生率（任何肿瘤小鼠的百分比）和肿瘤总重量（每只发生肿瘤的小鼠）不到CO/CO组的一半。在170日龄时，CA/CO组每只小鼠的肿瘤总重量显著减少，如果肿瘤发生，肿瘤生长速度为CO/CO组的一半。这些结果表明，母亲食用菜籽油与乳腺肿瘤的延迟出现和肿瘤生长减缓有关。用菜籽油代替玉米油对人们来说是一种简单的饮食改变；这种对母亲饮食的改变可能会降低女儿患乳腺癌的风险。
Maternal consumption of a diet high in omega 6 polyunsaturated fats (n-6 PUFA) has been shown to increase risk whereas a diet high in omega 3 polyunsaturated fats (n-3 PUFA) from fish oil has been shown to decrease risk for mammary gland cancer in female offspring of rats. The aim of this study was to determine whether increasing n-3 PUFA and reducing n-6 PUFA by using canola oil instead of corn oil in the maternal diet might reduce the risk for breast cancer in female offspring. Female SV 129 mice were divided into two groups and placed on diets containing either 10% w/w corn oil (which is 50% n-6 PUFA, control diet) or 10% w/w canola oil (which is 20% n-6 PUFA, 10% n-3 PUFA, test diet). After two weeks on the diets the females were bred with homozygous C3(1) TAg transgenic mice. Mother mice consumed the assigned diet throughout gestation and nursing of the offspring. After weaning, all female offspring were maintained on the control diet. Compared to offspring of mothers fed the corn oil diet (CO/CO group), offspring of mothers fed the canola oil diet (CA/CO group) had significantly fewer mammary glands with tumors throughout the experiment. At 130 days of age, the CA/CO group had significantly fewer tumors per mouse (multiplicity); the tumor incidence (fraction of mice with any tumor) and the total tumor weight (per mouse that developed tumor) was less than one half that of the CO/CO group. At 170 days of age, the total tumor weight per mouse was significantly less in the CA/CO group and if a tumor developed the rate of tumor growth rate was half that of CO/CO group. These results indicate that maternal consumption of canola oil was associated with delayed appearance of mammary gland tumors and slowed growth of the tumors that developed. Substituting canola oil for corn oil is an easy dietary change for people to make; such a change to the maternal diet may decrease risk for breast cancer in the daughter.
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影响因子：
64.5
作者：
DYSON, N;BUCHKOVICH, K;HARLOW, E
通讯作者：
HARLOW, E
影响因子：
1.9
作者：
Clarke, RG;Lund, EK;Johnson, IT
通讯作者：
Johnson, IT
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5.8
作者：
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8.8
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影响因子：
2.9
作者：
Hardman, W. Elaine
通讯作者：
Hardman, W. Elaine