The relationship between the presence of chromosomal instability and prognosis of squamous cell carcinoma of the lung: fluorescence in situ hybridization analysis of paraffin-embedded tissue from 47 Korean patients.
The relationship between the presence of chromosomal instability and prognosis of squamous cell carcinoma of the lung: fluorescence in situ hybridization analysis of paraffin-embedded tissue from 47 Korean patients.
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DOI：
10.3346/jkms.2010.25.6.863
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发表时间：
2010-06
影响因子：
4.5
通讯作者：
Choi CM
中科院分区：
文献类型：
--
作者：
Yoo JW;Seo KW;Jang SJ;Oh YM;Shim TS;Kim WS;Lee DS;Lee SD;Choi CM
为了评估染色体不稳定性（CIN）在肺鳞状细胞癌（SCC）中的预后重要性，研究了荧光原位杂交（FISH）检测的CIN与SCC患者生存率之间的关系。分析了47例肺鳞癌手术标本。为了鉴定具有CIN的肿瘤，对从石蜡包埋的肿瘤组织中提取的细胞核进行c-myc、6号染色体、EGFR和5号染色体的p16和多靶DNA FISH测定（LAVysion，Vysis）。生存率在年龄、T因子、N因子、CIN和吸烟状况方面进行比较。如果五条染色体中至少有四条呈阳性，则该样本被定义为CIN阳性。在47例标本中，9例（19%）为CIN阳性。总生存率为66%。CIN阳性患者的总生存率估计为33.3%，CIN阴性患者的总生存率估计为76.7%（风险比3.47; 95%置信区间，1.25-9.67; P=0.017）。在多变量分析中，CIN的存在是生存的预测因素。FISH检测CIN阳性可作为肺鳞癌的预后指标。
To evaluate the prognostic importance of chromosomal instability (CIN) in squamous cell carcinoma (SCC) of the lung, the relationship between CIN detected by fluorescence in situ hybridization (FISH) and survival in SCC patients was examined. Forty-seven surgical specimens of lung SCC were analyzed. To identify tumors with CIN, p16 and multi-target DNA FISH assays for c-myc, chromosome 6, EGFR, and chromosome 5 (LAVysion, Vysis) were performed on nuclei extracted from paraffin-embedded tumor tissues. Survival rates were compared in terms of age, T factor, N factor, CIN, and smoking status. A sample was defined as CIN-positive if at least four of the five chromosomes were positive. Among the 47 specimens, 9 (19%) were CIN-positive. The overall survival rate was 66%. Overall survival rates were estimated as 33.3% for CIN-positive patients and 76.7% for CIN-negative patients (Hazard ratio 3.47; 95% Confidence interval, 1.25-9.67; P=0.017). In multivariate analysis, the presence of CIN was a predictive factor for survival. CIN-positive based on FISH can be prognostic factor of lung SCC.
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影响因子：
3.7
作者：
STOCK, C;AMBROS, IM;AMBROS, PF
通讯作者：
AMBROS, PF
影响因子：
5.3
作者：
Tseng, Ruo-Chia;Hsieh, Feng-Jen;Wang, Yi-Ching
通讯作者：
Wang, Yi-Ching
影响因子：
11.2
作者：
Fonseca, Rafael;Barlogie, Bart;Avet-Loiseau, Herve
通讯作者：
Avet-Loiseau, Herve
DOI：
10.1164/rccm.200708-1142oc
发表时间：
2008-02-01
影响因子：
24.7
作者：
Jonsson, Steinn;Varella-Garcia, Marileila;Franklin, Wilbur A.
通讯作者：
Franklin, Wilbur A.
影响因子：
5.3
作者：
Yakut, Tahsin;Schulten, Hans-Juergen;Fuezesi, Laszlo
通讯作者：
Fuezesi, Laszlo