The longitudinal association between changes in lung function and changes in abdominal visceral obesity in Korean non-smokers.
The longitudinal association between changes in lung function and changes in abdominal visceral obesity in Korean non-smokers.
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DOI：
10.1371/journal.pone.0193516
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Kim JS
中科院分区：
文献类型：
--
作者：
Choe EK;Kang HY;Lee Y;Choi SH;Kim HJ;Kim JS
肥胖，特别是腹部肥胖，可能与肺功能下降有关。我们的目的是通过一项纵向队列研究，调查肥胖指数是否与无症状非吸烟者的第一秒用力呼气量（FEV1）和用力肺活量（FVC）相关。回顾性审查和分析了1，145名受试者（428名男性，平均年龄52.3岁）的临床记录，这些受试者在2007年至2014年期间至少接受了两次全面的健康评估，包括肺功能测定和腹部脂肪计算机断层扫描。平均随访时间为1，105天（超过3.0年）。基线总脂肪组织（达特）和内脏脂肪组织（VAT）与FEV1和FVC呈负相关（P < 0.05）。纵向研究发现，男性和女性达特和VAT增加与FEV1和FVC降低显著相关，达特和VAT降低与FEV1和FVC增加显著相关（P < 0.05）。这些关联的强度和一致性在男性中比在女性中更明显。然而，皮下脂肪组织的变化和肺功能的变化之间没有显着的关系。在韩国非吸烟者中，腹部内脏脂肪的纵向变化与肺功能的变化呈负相关，平均时间为3年。这些结果表明，减少腹部内脏肥胖可以增加肺功能，尽管老化。
Obesity, particularly abdominal obesity, might be related to decreased lung function. We aimed to investigate whether obesity indices are associated with forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) in asymptomatic non-smokers through a longitudinal cohort study. The clinical records of 1,145 subjects (428 males, mean age 52.3 years) who underwent a comprehensive health evaluation, including spirometry and abdominal fat computed tomography, at least twice between 2007 and 2014 were retrospectively reviewed and analysed. The mean follow-up period was 1,105 days (over 3.0 years). The baseline total adipose tissue (TAT) and visceral adipose tissue (VAT) were inversely associated with both FEV1 and FVC (P < 0.05). The longitudinal study found that increasing TAT and VAT were significantly related to decreasing FEV1 and FVC, whereas decreasing TAT and VAT were related to increasing FEV1 and FVC in both males and females (P < 0.05). The strength and consistency of these associations were clearer in males than in females. However, no significant relationship was found between changes in subcutaneous adipose tissue and changes in lung function. In Korean non-smokers, longitudinal changes in abdominal visceral fat were found to be inversely related to changes in lung function over a mean period of three years. These results suggest that decreasing abdominal visceral obesity could increase lung function despite ageing.
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影响因子：
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作者：
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