Versatile use of bat ACE2 for cellular entry by MERS-CoV-like viruses.

Versatile use of bat ACE2 for cellular entry by MERS-CoV-like viruses.
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DOI:
10.1016/j.chom.2022.12.013
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发表时间:
2023-02-08
影响因子:
30.3
通讯作者:
Banerjee, Arinjay
Banerjee, Arinjay
中科院分区:
医学1区
文献类型:
--
作者:
Baid, Kaushal;Banerjee, Arinjay

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蝙蝠 MERS-CoV 样病毒 NeoCoV 和 PDF-2180 的细胞进入受体尚不清楚,因此它们的人畜共患潜力不明确。 Xiong 等人最近的一项研究。发表在《自然》杂志上的文章将蝙蝠 ACE2 确定为这两种病毒的细胞进入受体,强调了冠状病毒利用一系列进入受体的能力。蝙蝠 MERS-CoV 样病毒 NeoCoV 和 PDF-2180 的细胞进入受体尚不清楚,因此它们的人畜共患潜力不明确。 Xiong 等人最近的一项研究。发表在《自然》杂志上的文章将蝙蝠 ACE2 确定为这两种病毒的细胞进入受体,强调了冠状病毒利用一系列进入受体的能力。
Cellular entry receptors for bat MERS-CoV-like viruses NeoCoV and PDF-2180 were unknown, leaving their zoonotic potential ambiguous. A recent study by Xiong et al. published in Nature identified bat ACE2 as the cellular entry receptor for both viruses, highlighting the ability of coronaviruses to utilize a range of entry receptors. Cellular entry receptors for bat MERS-CoV-like viruses NeoCoV and PDF-2180 were unknown, leaving their zoonotic potential ambiguous. A recent study by Xiong et al. published in Nature identified bat ACE2 as the cellular entry receptor for both viruses, highlighting the ability of coronaviruses to utilize a range of entry receptors.
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