Loss of longitudinal superiority marks the microarchitecture deterioration of osteoporotic cancellous bones
Loss of longitudinal superiority marks the microarchitecture deterioration of osteoporotic cancellous bones
复制标题
纵向优势的丧失标志着骨质疏松松质骨微结构的恶化
DOI：
10.1007/s10237-021-01491-z
复制
发表时间：
2021-07
影响因子：
3.5
通讯作者：
Cai Lin
中科院分区：
文献类型：
--
作者：
Li Zhenzi;Liu Pan;Yuan Yanan;Liang Xiaoxiao;Lei Jun;Zhu Xiaobin;Zhang Zuoqi;Cai Lin
骨质疏松症(OP)是一种使骨骼机械性退化、易骨折的骨骼疾病，因其高患病率而成为全球性的公共卫生问题。已有研究表明，除骨质丢失外，微结构的降解在OP骨的力学退化中起着至关重要的作用，但微结构在OP中的具体作用尚未从力学的角度得到很好的阐明和量化。在这里，我们通过基于μCT的数字建模和对健康和卵巢切除诱导的骨质疏松小鼠骨样本的有限元模拟，成功地解耦并确定了微结构、骨量和组织特性在松质骨失效特性中的具体作用。结果表明，健康骨的微结构在有效刚度、强度和韧性等力学性能方面表现出纵向优势，适合于承受纵向载荷。OP不仅会减少骨量，还会破坏微结构的拓扑结构。前者主要是造成骨的机械性大小退化，而后者则是导致其功能崩溃的原因--有利的各向异性，即纵向优势。因此，我们将微结构劣化导致的材料与载荷之间的方向失配确定为OP的危险特征，并定义纵向优势指数作为衡量骨微结构健康状态的指标。这些发现为OP的诊断和治疗评估提供了有用的见解和指南。
Osteoporosis (OP), a skeletal disease making bone mechanically deteriorate and easily fracture, is a global public health issue due to its high prevalence. It has been well recognized that besides bone loss, microarchitecture degradation plays a crucial role in the mechanical deterioration of OP bones, but the specific role of microarchitecture in OP has not been well clarified and quantified from mechanics perspective. Here, we successfully decoupled and identified the specific roles of microarchitecture, bone mass and tissue property in the failure properties of cancellous bones, throughμCT-based digital modeling and finite element method simulations on bone samples from healthy and ovariectomy-induced osteoporotic mice. The results show that the microarchitecture of healthy bones exhibits longitudinal superiority in mechanical properties such as the effective stiffness, strength and toughness, which fits them well to bearing loads along their longitudinal direction. OP does not only reduce bone mass but also impair the microarchitecture topology. The former is mainly responsible for the mechanical degradation of bones in magnitude, wherever the latter accounts for the breakdown of their function-favorable anisotropy, the longitudinal superiority. Hence, we identified the microarchitecture-deterioration-induced directional mismatch between material and loading as a hazardous feature of OP and defined a longitudinal superiority index as measurement of the health status of bone microarchitecture. These findings provide useful insights and guidelines for OP diagnosis and treat assessment.
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DOI：
10.3233/thc-1998-65-615
发表时间：
1998-12
期刊：
Technology and health care : official journal of the European Society for Engineering and Medicine
影响因子：
--
作者：
P. Zysset;X. Guo;C. E. Hoffler;K. E. Moore;S. Goldstein
通讯作者：
P. Zysset;X. Guo;C. E. Hoffler;K. E. Moore;S. Goldstein
DOI：
10.1016/j.jmbbm.2017.12.010
发表时间：
2018-03
影响因子：
3.9
作者：
Barak MM;Black MA
通讯作者：
Black MA
DOI：
10.1243/emed_jour_1986_015_039_02
发表时间：
1986-07-01
期刊：
Engineering in medicine
影响因子：
--
作者：
Currey, J D
通讯作者：
Currey, J D
影响因子：
3.5
作者：
Harrison, Noel M.;McDonnell, Pat;McHugh, Peter E.
通讯作者：
McHugh, Peter E.
影响因子：
5.4
作者：
Thurner, P. J.;Erickson, B.;Hansma, P. K.
通讯作者：
Hansma, P. K.