The role of the hippocampus in avoidance learning and anxiety vulnerability.
The role of the hippocampus in avoidance learning and anxiety vulnerability.
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DOI：
10.3389/fnbeh.2014.00273
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发表时间：
2014
影响因子：
3
通讯作者：
Pang KC
中科院分区：
文献类型：
--
作者：
Cominski TP;Jiao X;Catuzzi JE;Stewart AL;Pang KC
海马体与焦虑症和创伤后应激障碍（PTSD）有关；人类研究表明，功能失调的海马体可能是PTSD发展的一个脆弱因素。在当前的研究中，我们研究了海马损伤对回避学习的影响，因为回避是所有焦虑症的核心症状。首先，研究了远交系大鼠海马损伤对回避学习的影响。其次，将Wistar-Kyoto （WKY）大鼠海马功能与SD大鼠进行比较。WKY大鼠是一种行为抑制的动物模型，行为抑制是焦虑的危险因素，它表现出异常的回避学习，其特征是促进回避习得和抵抗灭绝。本研究结果表明，SD大鼠海马损伤导致与WKY大鼠相似的回避学习消退功能受损。此外，与SD大鼠相比，WKY大鼠海马体积减少，海马突触可塑性受损。这些结果表明，海马功能障碍增强了持续回避反应的发展，因此可能导致焦虑障碍和创伤后应激障碍的发展。
The hippocampus has been implicated in anxiety disorders and post-traumatic stress disorder (PTSD); human studies suggest that a dysfunctional hippocampus may be a vulnerability factor for the development of PTSD. In the current study, we examined the effect of hippocampal damage in avoidance learning, as avoidance is a core symptom of all anxiety disorders. First, the effect of hippocampal damage on avoidance learning was investigated in outbred Sprague Dawley (SD) rats. Second, the function of the hippocampus in Wistar-Kyoto (WKY) rats was compared to SD rats. The WKY rat is an animal model of behavioral inhibition, a risk factor for anxiety, and demonstrates abnormal avoidance learning, marked by facilitated avoidance acquisition and resistance to extinction. The results of the current study indicate that hippocampal damage in SD rats leads to impaired extinction of avoidance learning similar to WKY rats. Furthermore, WKY rats have reduced hippocampal volume and impaired hippocampal synaptic plasticity as compared to SD rats. These results suggest that hippocampal dysfunction enhances the development of persistent avoidance responding and, thus, may confer vulnerability to the development of anxiety disorders and PTSD.
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影响因子：
3.5
作者：
Bremner, JD
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Bremner, JD
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作者：
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作者：
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