DNA sequence of the herpes simplex virus type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus.
DNA sequence of the herpes simplex virus type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus.
复制标题
编码糖蛋白 gH 的单纯疱疹病毒 1 型基因的 DNA 序列，以及水痘带状疱疹病毒和 Epstein-Barr 病毒基因组中同源物的鉴定。
作者：
D. McGeoch;A. Davison
我们已经确定了先前绘制的糖蛋白gH表位编码序列位置周围的1型单纯疱疹病毒DNA序列，并推导了gH基因的结构和gH的氨基酸序列。未加工的多肽预计含有838个氨基酸，并具有N端信号序列和C端跨膜序列。温度敏感突变体 tsQ26 位于预测的 gH 编码序列内。在另外两种疱疹病毒（即水痘带状疱疹病毒和 Epstein-Barr 病毒）的基因组中鉴定出同源基因。
We have determined the sequence of herpes simplex virus type 1 DNA around the previously mapped location of sequences encoding an epitope of glycoprotein gH, and have deduced the structure of the gH gene and the amino acid sequence of gH. The unprocessed polypeptide is predicted to contain 838 amino acids, and to possess an N-terminal signal sequence and a C-terminal transmembrane sequence. Temperature-sensitive mutant tsQ26 maps within the predicted gH coding sequence. Homologous genes were identified in the genomes of two other herpesviruses, namely varicella-zoster virus and Epstein-Barr virus.
HSV-1 温度敏感突变体的遗传分析：结合使用互补和物理作图进行顺反子分配。
影响因子：
3.7
作者：
Weller,SK;Aschman,DP;Sacks,WR;Coen,DM;Schaffer,PA
通讯作者：
Schaffer,PA
1型单纯疱疹病毒胸苷激酶基因的核苷酸序列。
DOI：
10.1073/pnas.78.3.1441
发表时间：
1981
影响因子：
11.1
作者：
Wagner,MJ;Sharp,JA;Summers,WC
通讯作者：
Summers,WC