Emerging roles of Sox6 in the renal and cardiovascular system.
Emerging roles of Sox6 in the renal and cardiovascular system.
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DOI：
10.14814/phy2.14604
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发表时间：
2020-11
影响因子：
2.5
通讯作者：
Gomez JA
中科院分区：
文献类型：
--
作者：
Saleem M;Barturen-Larrea P;Gomez JA
性别决定区Y （SRY）相关的高迁移率群盒（Sox）转录因子家族在胚胎发育过程中决定细胞命运的功能已经得到了很好的证实。越来越多的证据表明，转录因子的Sox家族是基本的成人组织稳态，再生和生理。SoxD基因亚家族在胚胎发育和成年期不同器官的各种细胞类型中表达，并在许多细胞系中参与细胞命运的决定、细胞增殖和存活、分化和终末成熟。SoxD蛋白（即Sox5、Sox6、Sox13和Sox23）功能失调与不同的疾病有关，如软骨发育不良、癌症、糖尿病、高血压、自身免疫性疾病、骨关节炎等。在这篇综述中，我们介绍了转录因子Sox6的最新进展，Sox6参与了许多疾病，如糖尿病肾病、脂肪生成、心肌病、炎症性肠病和癌症。Sox6参与了小鼠在钠耗尽和脱水期间肾素表达和JG细胞募集的调节。我们提供了近五年来Sox6的研究进展，以及Sox6功能在心血管生理和疾病状况中的意义。性别决定区Y （SRY）相关的高迁移率群盒（Sox）转录因子家族在胚胎发育过程中决定细胞命运的功能已经得到了很好的证实。SoxD基因亚家族在胚胎发生和成年期间在不同器官的各种细胞类型中表达，SoxD蛋白（即Sox5、Sox6、Sox13和Sox23）功能失调与不同的疾病状况有关。在这篇综述中，我们介绍了转录因子Sox6的最新进展，Sox6参与了许多疾病，如糖尿病肾病、脂肪生成、心肌病、炎症性肠病和癌症。我们提供了近五年来Sox6的研究进展，以及Sox6功能在心血管生理和疾病状况中的意义。
The function of Sex‐determining Region Y (SRY)‐related high‐mobility‐group box (Sox) family of transcription factors in cell fate decisions during embryonic development are well‐established. Accumulating evidence indicates that the Sox family of transcription factors are fundamental in adult tissue homeostasis, regeneration, and physiology. The SoxD subfamily of genes are expressed in various cell types of different organs during embryogenesis and adulthood and have been involved in cell‐fate determination, cellular proliferation and survival, differentiation, and terminal maturation in a number of cell lineages. The dysregulation in the function of SoxD proteins (i.e. Sox5, Sox6, Sox13, and Sox23) have been implicated in different disease conditions such as chondrodysplasia, cancer, diabetes, hypertension, autoimmune diseases, osteoarthritis among others. In this minireview, we present recent developments related to the transcription factor Sox6, which is involved in a number of diseases such as diabetic nephropathy, adipogenesis, cardiomyopathy, inflammatory bowel disease, and cancer. Sox6 has been implicated in the regulation of renin expression and JG cell recruitment in mice during sodium depletion and dehydration. We provide a current perspective of Sox6 research developments in last five years, and the implications of Sox6 functions in cardiovascular physiology and disease conditions. The function of Sex‐determining Region Y (SRY)‐related high‐mobility‐group box (Sox) family of transcription factors in cell fate decisions during embryonic development are well‐established. The SoxD subfamily of genes are expressed in various cell types of different organs during embryogenesis and adulthood and dysregulation in the function of SoxD proteins (i.e. Sox5, Sox6, Sox13, and Sox23) have been implicated in different disease conditions. In this minireview, we present recent developments related to the transcription factor Sox6, which is involved in a number of diseases such as diabetic nephropathy, adipogenesis, cardiomyopathy, inflammatory bowel disease, and cancer. We provide a current perspective of Sox6 research developments in last five years, and the implications of Sox6 functions in cardiovascular physiology and disease conditions.
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影响因子：
2.5
作者：
Hagiwara, Nobuko
通讯作者：
Hagiwara, Nobuko
影响因子：
64.5
作者：
Kinchen J;Chen HH;Parikh K;Antanaviciute A;Jagielowicz M;Fawkner-Corbett D;Ashley N;Cubitt L;Mellado-Gomez E;Attar M;Sharma E;Wills Q;Bowden R;Richter FC;Ahern D;Puri KD;Henault J;Gervais F;Koohy H;Simmons A
通讯作者：
Simmons A
影响因子：
5.3
作者：
Han, Yu;Lefebvre, Veronique
通讯作者：
Lefebvre, Veronique
影响因子：
4.8
作者：
Iguchi, H;Ikeda, Y;Sakai, J
通讯作者：
Sakai, J
影响因子：
5.1
作者：
Cho, N. H.;Shaw, J. E.;Malanda, B.
通讯作者：
Malanda, B.