Mesoscale cortical dynamics reflect the interaction of sensory evidence and temporal expectation during perceptual decision-making.
Mesoscale cortical dynamics reflect the interaction of sensory evidence and temporal expectation during perceptual decision-making.
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DOI：
10.1016/j.neuron.2021.03.031
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发表时间：
2021-06-02
期刊：
影响因子：
16.2
通讯作者：
Znamenskiy P
中科院分区：
文献类型：
--
作者：
Orsolic I;Rio M;Mrsic-Flogel TD;Znamenskiy P
感官证据如何在多个大脑区域之间转换以影响行为仍然知之甚少。我们在一项视觉变化检测任务中训练小鼠，该任务旨在将选择的隐蔽前因与执行相关的活动分开。背侧皮层的宽场钙成像显示了这些过程背后的根本不同的活动动力学。虽然信号执行的选择是广泛的，波动的感觉证据在没有明显的运动反应引发了一个有限的活动级联，开始与视觉皮层的短暂调制，其次是持续招聘的次级和初级运动皮层。动物对刺激可能发生变化的预期调节了感觉证据对运动皮层的激活。这些结果揭示了不同的激活时间尺度的特定皮层区域的感官证据在决策过程中，并表明，招聘的运动皮层依赖于感官证据和时间的期望的相互作用。小鼠进行视觉变化检测任务的基础上不确定的感觉证据任务设计分离的审议和行动执行的过程中的感觉证据调制的次级运动皮层在没有运动这些反应是选择性的，持续的，并调制的时间预期Orsolo等。揭示了在视觉变化检测任务中，小鼠新皮层是如何被感觉证据调制的。他们表明，次级运动皮层的招募与学习有关，反映了感觉证据和任务结构先验知识的相互作用。
How sensory evidence is transformed across multiple brain regions to influence behavior remains poorly understood. We trained mice in a visual change detection task designed to separate the covert antecedents of choices from activity associated with their execution. Wide-field calcium imaging across the dorsal cortex revealed fundamentally different dynamics of activity underlying these processes. Although signals related to execution of choice were widespread, fluctuations in sensory evidence in the absence of overt motor responses triggered a confined activity cascade, beginning with transient modulation of visual cortex and followed by sustained recruitment of the secondary and primary motor cortex. Activation of the motor cortex by sensory evidence was modulated by animals’ expectation of when the stimulus was likely to change. These results reveal distinct activation timescales of specific cortical areas by sensory evidence during decision-making and show that recruitment of the motor cortex depends on the interaction of sensory evidence and temporal expectation. Mice performed a visual change detection task based on uncertain sensory evidence Task design separated the processes of deliberation and action execution Sensory evidence modulated secondary motor cortex in absence of movement These responses were selective, sustained, and modulated by temporal expectation Orsolic et al. reveal how the mouse neocortex is modulated by sensory evidence in a visual change detection task. They show that recruitment of the secondary motor cortex emerges with learning and reflects the interaction of sensory evidence and prior knowledge of task structure.
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影响因子：
8.8
作者：
Burgess CP;Lak A;Steinmetz NA;Zatka-Haas P;Bai Reddy C;Jacobs EAK;Linden JF;Paton JJ;Ranson A;Schröder S;Soares S;Wells MJ;Wool LE;Harris KD;Carandini M
通讯作者：
Carandini M
视觉皮层单细胞投射的逻辑。
影响因子：
64.8
作者：
Han Y;Kebschull JM;Campbell RAA;Cowan D;Imhof F;Zador AM;Mrsic-Flogel TD
通讯作者：
Mrsic-Flogel TD
影响因子：
25
作者：
Jaramillo, Santiago;Zador, Anthony M.
通讯作者：
Zador, Anthony M.
影响因子：
64.8
作者：
Hanks TD;Kopec CD;Brunton BW;Duan CA;Erlich JC;Brody CD
通讯作者：
Brody CD
DOI：
10.1523/jneurosci.2894-10.2010
发表时间：
2010-11-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ding L;Gold JI
通讯作者：
Gold JI