The structure of genetic and environmental risk factors for DSM-IV personality disorders: a multivariate twin study.
The structure of genetic and environmental risk factors for DSM-IV personality disorders: a multivariate twin study.
复制标题
DOI：
10.1001/archpsyc.65.12.1438
复制
发表时间：
2008-12
影响因子：
--
通讯作者：
Reichborn-Kjennerud, Ted
中科院分区：
文献类型：
--
作者：
Kendler, Kenneth S.;Aggen, Steven H.;Czajkowski, Nikolai;Roysamb, Espen;Tambs, Kristian;Torgersen, Svenn;Neale, Michael C.;Reichborn-Kjennerud, Ted
虽然遗传和环境因素都会影响个体人格障碍（PD）的风险，但我们对《精神疾病诊断与统计手册（第四版）》（DSM-IV）中PD之间的共病模式知之甚少。阐明10个DSM-IV PD的遗传和环境风险因素的结构。个人访谈和Mx程序多变量双胞胎模型中PD的评估。一般社区。共有2794名挪威公共卫生研究所双胞胎小组的年轻成年成员。10个DSM-IV PD的认可标准数量。最佳拟合的多变量双胞胎模型需要3个遗传因素和3个个体特异性环境因素以及每个PD特有的遗传和个体特异性因素。第一个遗传因素在所有3个集群的PD上都有很高的负荷，包括偏执狂、表演型、边缘型、自恋型、依赖型和强迫型。第二个遗传因素只有在边缘型和反社会型PD上才有显著的负荷。第三个遗传因子仅对类焦虑型和回避型PD有高负荷。一些PD有大量的疾病特异性遗传风险因素。第一、第二和第三个个体特异性环境因素分别对集群B、A和C PD具有高负荷，只有一个例外：强迫性PD负荷集群B而不是集群C PD。DSM-IV PD的遗传风险因素并不反映A、B和C簇类型。相反，1个遗传因素反映了对PD病理和/或负面情绪的广泛脆弱性。另外两个遗传因素更具体，反映了高冲动/低宜人性和内向。出乎意料的是，集群A，B，和C的类型很好地反映在环境风险因素的结构，这表明环境的经验可能是负责集群A，B，和C PD的趋势，共同发生。
Although both genetic and environmental factors affect risk of individual personality disorders (PDs), we know little of how they contribute to the pattern of comorbidity between the PDs in the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV). To clarify the structure of the genetic and environmental risk factors for the 10 DSM-IV PDs. Assessment of PDs at personal interview and multivariate twin modeling with the Mx program. General community. A total of 2794 young adult members of the Norwegian Institute of Public Health Twin Panel. Number of endorsed criteria for the 10 DSM-IV PDs. The best-fit multivariate twin model required 3 genetic and 3 individual-specific environmental factors and genetic and individual-specific factors unique to each PD. The first genetic factor had high loadings on PDs from all 3 clusters including paranoid, histrionic, borderline, narcissistic, dependent, and obsessive-compulsive. The second genetic factor had substantial loadings only on borderline and antisocial PD. The third genetic factor had high loadings only on schizoid and avoidant PD. Several PDs had substantial disorder-specific genetic risk factors. The first, second, and third individual-specific environmental factors had high loadings on the cluster B, A, and C PDs, respectively, with 1 exception: obsessive-compulsive PD loaded with cluster B and not cluster C PDs. Genetic risk factors for DSM-IV PDs do not reflect the cluster A, B, and C typology. Rather, 1 genetic factor reflects a broad vulnerability to PD pathology and/or negative emotionality. The 2 other genetic factors are more specific and reflect high impulsivity/low agreeableness and introversion. Unexpectedly, the cluster A, B, and C typology is well reflected in the structure of environmental risk factors, suggesting that environmental experiences may be responsible for the tendency of cluster A, B, and C PDs to co-occur.
登录
查看更多内容
影响因子：
17.7
作者：
Helgeland, MI;Kjelsberg, E;Torgersen, S
通讯作者：
Torgersen, S
影响因子：
3
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
4.3
作者：
Austin, EJ;Deary, IJ
通讯作者：
Deary, IJ
影响因子：
--
作者：
Kendler, KS;Prescott, CA;Neale, MC
通讯作者：
Neale, MC
影响因子：
--
作者：
Asarnow, RF;Nuechterlein, KH;Kendler, KS
通讯作者：
Kendler, KS