Vital exhaustion and sudden cardiac death in the Atherosclerosis Risk in Communities Study.
Vital exhaustion and sudden cardiac death in the Atherosclerosis Risk in Communities Study.
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DOI：
10.1136/heartjnl-2017-311825
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Rosamond WD
中科院分区：
文献类型：
--
作者：
Bogle BM;Sotoodehnia N;Kucharska-Newton AM;Rosamond WD
生命衰竭(VE)，一种被定义为缺乏能量，增加疲倦和易怒，以及士气低落的结构，与心血管事件有关。在社区动脉粥样硬化风险(ARIC)研究中，我们试图研究VE与心脏性猝死(SCD)的关系。ARIC的研究是一个以混血为主的男性和女性队列，基线年龄在45-之间，于1987年开始，通过在美国4个社区随机抽样。使用马斯特里赫特问卷对13,923名个体的生命衰竭(VE)进行了测量。用COX比例风险模型检验VE评分与出院后SCD的危险性。截至2012年，ARIC中通过医生记录审查确定了457例SCD病例，这些病例被定义为一种突发的无脉搏状态，推测是由于先前稳定的个人的室性快速性心律失常。对年龄、性别和种族中心进行调整后，VE最高的三分位数的参与者患SCD的风险增加(HR=1.48 95%CI：1.17-1.87)，但在调整已有的心血管疾病危险因素后，这些发现并不显著(HR=0.94 95%CI：0.73-1.20)。在ARIC研究的参与者中，在调整心血管危险因素后，VE与SCD风险增加无关。
Vital exhaustion (VE), a construct defined as lack of energy, increased fatigue and irritability, and feelings of demoralization, has been associated with cardiovascular events. We sought to examine the relation between VE and sudden cardiac death (SCD) in the Atherosclerosis Risk in Communities (ARIC) Study. The ARIC Study is a predominately biracial cohort of men and women, aged 45-64 at baseline, initiated in 1987 through random sampling in 4 US communities. Vital exhaustion (VE) was measured using the Maastricht questionnaire between 1990-1992 among 13,923 individuals. Cox proportional hazards models were used to examine the hazard of out-of-hospital SCD across tertiles of VE scores. Through 2012, 457 SCD cases, defined as a sudden pulseless condition presumed due to a ventricular tachyarrhythmia in a previously stable individual, were identified in ARIC by physician record review. Adjusting for age, sex, and race-center, participants in the highest VE tertile had an increased risk of SCD (HR=1.48 95% CI: 1.17-1.87), but these findings did not remain significant after adjustment for established cardiovascular disease risk factors (HR=0.94 95% CI: 0.73-1.20). Among participants of the ARIC study, VE was not associated with an increased risk for SCD after adjustment for cardiovascular risk factors.
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影响因子：
4.7
作者：
APPELS, A;MULDER, P
通讯作者：
MULDER, P
影响因子：
3.7
作者：
Maheshwari, Ankit;Norby, Faye L.;Chen, Lin Y.
通讯作者：
Chen, Lin Y.
影响因子：
4.8
作者：
Ni, Hanyu;Coady, Sean;Rosamond, Wayne;Folsom, Aaron R.;Chambless, Lloyd;Russell, Stuart D.;Sorlie, Paul D.
通讯作者：
Sorlie, Paul D.
影响因子：
5.4
作者：
Bogle BM;Ning H;Mehrotra S;Goldberger JJ;Lloyd-Jones DM
通讯作者：
Lloyd-Jones DM
影响因子：
22.8
作者：
APPELS, A
通讯作者：
APPELS, A