Pregnant rats show enhanced spatial memory, decreased anxiety, and altered levels of monoaminergic neurotransmitters.
Pregnant rats show enhanced spatial memory, decreased anxiety, and altered levels of monoaminergic neurotransmitters.
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DOI：
10.1016/j.brainres.2008.09.006
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发表时间：
2008-11-19
期刊：
影响因子：
2.9
通讯作者：
Luine VN
中科院分区：
文献类型：
--
作者：
Macbeth AH;Gautreaux C;Luine VN
在妊娠第7-9天（GD 7、GD 9）和妊娠第16-18天（GD 16、GD 18）两个时间段内，测量了非妊娠（NP）和妊娠女性的空间记忆、焦虑和中枢单胺能活动。怀孕的女性区分对象位置在两个测试日的对象放置任务，而NP女性无法区分位置。与NP雌性动物相比，妊娠雌性动物在GD 9时高架十字迷宫中的焦虑减少，随后在GD 18时高架十字迷宫中的焦虑样行为增加。单胺水平和活性（以周转率为指标）在前额叶皮层（PFC），海马CA 1和CA 3区（对记忆很重要的区域），以及内侧视前区（mPOA，一个重要的区域，在显示母亲的行为）进行了测量。在PFC中，NP雌性动物的单胺水平和转换率通常较高;然而，在GD 18时，妊娠雌性动物的去甲肾上腺素（NE）转换率较高。在海马CA 1和CA 3区，单胺水平和周转率在怀孕期间普遍较高，特别是在GD 9。在mPOA中，妊娠与NE活性增加相关，这是以前未报道的发现。本研究扩展了现有的研究，表明怀孕有利于空间记忆，并可能减少焦虑。单胺水平和特定脑区活动的变化表明，多巴胺、去甲肾上腺素和5-羟色胺系统可能有助于观察到的行为差异。
Spatial memory, anxiety and central monoaminergic activities were measured in non-pregnant (NP) and pregnant females during two time periods of pregnancy: gestational day 7–9 (GD7, GD9) & gestation day 16–18 (GD16, GD18). Pregnant females discriminated between object locations on both test days on an object placement task, whereas NP females were unable to discriminate between locations. Pregnant females displayed decreased anxiety on the elevated plus maze on GD9 compared to NP females, followed by increased anxiety-like behavior on the elevated plus maze on GD18. Monoamine levels and activity (as indexed by turnover ratio) were measured in prefrontal cortex (PFC), CA1 and CA3 regions of the hippocampus (areas important for memory), and medial preoptic area (mPOA, an area important in display of maternal behaviors). In the PFC, NP females generally had higher monoamine levels and turnover ratios; however, norepinephrine (NE) turnover was higher in pregnant females at GD18. In the CA1 and CA3 regions of the hippocampus, monoamine levels and turnover ratios were generally higher during pregnancy, particularly on GD9. In the mPOA, pregnancy was associated with increases in NE activity, a previously unreported finding. The present study expands upon existing research indicating that pregnancy is beneficial to spatial memory and may decrease anxiety. Changes in monoamine levels and activity in specific brain regions indicate that the dopamine, norepinephrine and serotonin systems may contribute to the observed behavioral differences.
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