Diverse myeloid cells are recruited to the developing and inflamed mammary gland.
Diverse myeloid cells are recruited to the developing and inflamed mammary gland.
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DOI：
10.1111/imm.13430
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发表时间：
2022-02
期刊：
影响因子：
6.4
通讯作者：
Graham GJ
中科院分区：
文献类型：
--
作者：
Wilson GJ;Fukuoka A;Vidler F;Graham GJ
免疫系统在乳腺中发挥着重要作用，在感染和癌症期间塑造发育过程并控制炎症。在这里，我们揭示了处女、怀孕、哺乳和退化小鼠乳腺以及乳汁发育过程中骨髓细胞区室中意想不到的异质性。我们研究了个体和复合趋化因子受体缺陷对细胞募集的功能影响。在无菌炎症和细菌感染模型中也显示了多样化的骨髓细胞募集。引人注目的是，我们已经证明炎症和感染可以改变青春期乳腺内关键发育结构——终芽的丰度。这种以前未知的青春期炎症负担的影响可能对理解青春期发育具有重要意义。在发育、无菌炎症和细菌感染过程中，多种骨髓细胞被招募到乳腺。炎症和感染可以改变腺体内的发育结构。
The immune system plays fundamental roles in the mammary gland, shaping developmental processes and controlling inflammation during infection and cancer.Here, we reveal unanticipated heterogeneity in the myeloid cell compartment duringdevelopment of virgin, pregnant, lactating and involuting mouse mammary glands,and in milk. We investigate the functional consequences of individual and compoundchemokine receptor deficiency on cell recruitment. Diverse myeloid cell recruitmentwas also shown in models of sterile inflammation and bacterial infection.Strikingly, we have shown that inflammation and infection can alter the abundanceof terminal end buds, a key developmental structure, within the pubertal mammarygland. This previously unknown effect of inflammatory burden during puberty couldhave important implications for understanding pubertal development. Diverse myeloid cells are recruited to the mammary gland during development, sterile inflammation and bacterial infection. Inflammation and infection can alter developmental structures within the gland.
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