Sources of group differences in functional connectivity: an investigation applied to autism spectrum disorder.
Sources of group differences in functional connectivity: an investigation applied to autism spectrum disorder.
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DOI：
10.1016/j.neuroimage.2009.07.051
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Birn, Rasmus M.
中科院分区：
文献类型：
--
作者：
Jones, Tyler B.;Bandettini, Peter A.;Kenworthy, Lauren;Case, Laura K.;Milleville, Shawn C.;Martin, Alex;Birn, Rasmus M.
越来越多的功能磁共振成像研究正在使用大脑区域之间低频波动的相关性来推断“功能连接”，这些低频波动被认为反映了神经元活动的同步变化。在自闭症谱系障碍（ASD）的研究中，通过专注于对任务调制的反应，仅使用休息时间或分析纯粹的休息状态数据，发现这种连接性的测量结果有所减少。然而，这种连接性的差异可能是由许多不同的机制造成的-噪音，任务相关波动，任务表现或自发神经元活动的差异。在这项研究中，我们调查了高功能ASD的青少年和典型的发展控制对象之间的功能连接的差异，通过检查的功能磁共振成像反应的顶部上发生的剩余波动，以公开的语言流畅性任务。我们发现这些残差的相关性降低（减少“连接”）在ASD的主题。此外，我们发现，这种减少是由于任务相关的影响，块到块的变化，在任务的性能，或增加噪音，和差异是最大的主要休息时间被认为是。这些发现表明，ASD中功能连接中断的估计可能是由与任务无关的神经元波动的差异驱动的。
An increasing number of fMRI studies are using the correlation of low-frequency fluctuations between brain regions, believed to reflect synchronized variations in neuronal activity, to infer “functional connectivity”. In studies of autism spectrum disorder (ASD), decreases in this measure of connectivity have been found by focusing on the response to task modulation, by using only the rest periods, or by analyzing purely resting-state data. This difference in connectivity, however, could result from a number of different mechanisms – differences in noise, task-related fluctuations, task performance, or spontaneous neuronal activity. In this study, we investigate the difference in functional connectivity between adolescents with high-functioning ASD and typically developing control subjects by examining the residual fluctuations occurring on top of the fMRI response to an overt verbal fluency task. We find decreased correlations of these residuals (a decreased “connectivity”) in ASD subjects. Furthermore, we find that this decrease was not due to task-related effects, block-to-block variations in task performance, or increased noise, and the difference was greatest when primarily rest periods are considered. These findings suggest that the estimate of disrupted functional connectivity in ASD is likely driven by differences in task-unrelated neuronal fluctuations.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Bullmore, ET;Horwitz, B;Sharma, T
通讯作者：
Sharma, T
影响因子：
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作者：
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通讯作者：
Cohen, MS
影响因子：
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作者：
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通讯作者：
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影响因子：
16.2
作者：
Bokde, ALW;Tagamets, MA;Horwitz, B
通讯作者：
Horwitz, B