Pan-cancer analysis combined with experimental validation revealed IL4I1 as an immunological and prognostic biomarker.
Pan-cancer analysis combined with experimental validation revealed IL4I1 as an immunological and prognostic biomarker.
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泛癌分析与实验验证相结合揭示了 IL4I1 作为免疫学和预后生物标志物。
DOI：
10.1016/j.intimp.2022.109091
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发表时间：
2022-08
影响因子：
5.6
通讯作者：
Dong Hanhua
中科院分区：
文献类型：
--
作者：
Rao Dean;Yu Chengpeng;Wang Tiantian;Sheng Jiaqi;Lv Enjun;Liang Huifang;Huang Wenjie;Dong Hanhua
白细胞介素 - 4诱导基因1（IL4I1）是一种分泌型L - 苯丙氨酸氧化酶，它可将苯丙氨酸脱氨生成苯丙酮酸，在此过程中释放过氧化氢（H₂O₂）和氨（NH₃）。IL4I1主要由炎症性抗原呈递细胞分泌，并参与适应性免疫应答的调节。此外，据报道IL4I1在多种肿瘤组织中过表达，并影响肿瘤的发展。我们利用公共数据库以及样本库的微阵列数据，探索了IL4I1的表达模式、与临床特征的相关性以及预后价值。随后，我们利用下载的数据对肿瘤基质细胞和免疫细胞浸润进行评分，并结合TIMER2.0和GEPIA数据库分析了IL4I1与免疫细胞或免疫相关分子之间的相关性。分析表明IL4I1与多种免疫细胞的浸润状态有关。最后，建立了稳定过表达IL4I1的肝细胞癌（HCC）细胞系，以研究IL4I1对细胞增殖和运动能力的影响。所有这些结果表明IL4I1是一个潜在的生物标志物和治疗靶点。
Interleukin-4-induced gene 1 (IL4I1) is a secreted l-phenylalanine oxidase that deaminates phenylalanine to phenylpyruvate, releasing H2O2 and NH3 in the process. IL4I1 is mainly secreted by inflammatory antigen presenting cells and is involved in the regulation of adaptive immune responses. Furthermore, it has been reported that IL4I1 is overexpressed in a variety of tumor tissues and affects tumor development. We explored the expression patterns, correlation with clinical traits and prognostic value of IL4I1 using public databases and microarray data from sample banks. Subsequently, we used the downloaded data to score tumor stromal cells and immune cell infiltration and analyzed the correlation between IL4I1 and immune cells or immune-related molecules in combination with TIMER2.0 and GEPIA databases. The analysis showed that IL4I1 was associated with the infiltration status of various immune cells. Finally, stable IL4I1-overexpressing hepatocellular carcinoma (HCC) cell lines were established to investigate the effect of IL4I1 on cell proliferation and motor capacity. All of these results suggest that IL4I1 is a potential biomarker and therapeutic target.
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GEPIA：用于癌症和正常基因表达谱和交互式分析的网络服务器。
影响因子：
14.9
作者：
Tang Z;Li C;Kang B;Gao G;Li C;Zhang Z
通讯作者：
Zhang Z
影响因子：
14.9
作者：
The Gene Ontology Consortium
通讯作者：
The Gene Ontology Consortium
影响因子：
20.3
作者：
Boulland, Marie-Laure;Marquet, Jeanine;Castellano, Flavia
通讯作者：
Castellano, Flavia
影响因子：
5.4
作者：
Lasoudris, Fanette;Cousin, Celine;Molinier-Frenkel, Valerie
通讯作者：
Molinier-Frenkel, Valerie
影响因子：
4.1
作者：
A. Smirnova;E. Wincent;Linda Vikström Bergander;T. Alsberg;J. Bergman;A. Rannug;U. Rannug
通讯作者：
A. Smirnova;E. Wincent;Linda Vikström Bergander;T. Alsberg;J. Bergman;A. Rannug;U. Rannug