Epigenetics and fetal adaptation to perinatal events: diversity through fidelity.
Epigenetics and fetal adaptation to perinatal events: diversity through fidelity.
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DOI：
10.2527/jas.2009-2352
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发表时间：
2010-04
影响因子：
3.3
通讯作者：
Lane RH
中科院分区：
文献类型：
--
作者：
Joss-Moore LA;Metcalfe DB;Albertine KH;McKnight RA;Lane RH
围产期损伤，包括胎儿营养不良和缺氧，与几种成人发病的代谢紊乱的易感性增加有关。这些包括心血管疾病、胰岛素抵抗和肥胖。然而，驱动长期表型后果的机制最近才开始阐明。围产期适应的主要机制是染色质的表观遗传修饰。在这种情况下，染色质的表观遗传修饰被认为是对围产期损伤的反应，以调节基因表达并最大限度地提高胎儿存活率。在这次研讨会的报告中，我们讨论了表观遗传学作为一种机制，围产期的适应，可以由发育中的胎儿。我们研究了使用多种体内模型的益处，以了解聚集在一起并导致围产期适应的信号的相互关系。IGF-1的表观遗传效应所产生的围产期的侮辱进行了讨论，是与这个复杂的领域的困难和挑战。总之，表观遗传学提供了一种调节基因转录的方法，从而使胎儿适应各种各样的条件。
Perinatal insults, including fetal undernutrition and hypoxia, are associated with an increased susceptibility to several adult-onset metabolic disorders. These include cardiovascular disease, insulin resistance, and obesity. However, the mechanisms driving the long-term phenotypic consequences have only recently begun to be elucidated. A primary mechanism accounting for perinatal adaptation is the epigenetic modification of chromatin. In this context, epigenetic modifications to chromatin are thought to arise in response to a perinatal insult in an effort to modulate gene expression and maximize fetal survival. In this symposium report, we discuss epigenetics as a mechanism by which perinatal adaptations can be made by the developing fetus. We examine the benefits of using multiple in vivo models to understand the interrelation of signals that come together and result in perinatal adaptation. Epigenetic effects on IGF-1 arising from a perinatal insult are discussed, as are the difficulties and challenges associated with this complex field. In conclusion, epigenetics provides a means of modulating gene transcription, thus allowing fetal adaptation to a broad variety of conditions.
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影响因子：
158.5
作者：
GULER, HP;ZAPF, J;FROESCH, ER
通讯作者：
FROESCH, ER
在怀孕期间喂养蛋白质限制饮食的大鼠后代中肝糖皮质激素受体的表观遗传调节改变的诱导表明，DNA甲基转移酶-1表达降低与DNA甲基化受损和组蛋白修饰的变化有关。
影响因子：
3.6
作者：
Lillycrop, Karen A.;Slater-Jefferies, Jo L.;Hanson, Mark A.;Godfrey, Keith M.;Jackson, Alan A.;Burdge, Graham C.
通讯作者：
Burdge, Graham C.
DOI：
10.1016/j.bbagrm.2008.07.009
发表时间：
2009-01
影响因子：
4.7
作者：
Marmorstein, Ronen;Trievel, Raymond C.
通讯作者：
Trievel, Raymond C.
影响因子：
2.9
作者：
Desai, Mina;Han, Guang;Lane, Robert H.
通讯作者：
Lane, Robert H.
影响因子：
--
作者：
Barker, DJP
通讯作者：
Barker, DJP