Leveraging blood and tissue CD4+ T cell heterogeneity at the single cell level to identify mechanisms of disease in rheumatoid arthritis.
Leveraging blood and tissue CD4+ T cell heterogeneity at the single cell level to identify mechanisms of disease in rheumatoid arthritis.
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DOI：
10.1016/j.coi.2017.08.005
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发表时间：
2017-12
影响因子：
7
通讯作者：
Raychaudhuri S
中科院分区：
文献类型：
--
作者：
Fonseka CY;Rao DA;Raychaudhuri S
CD4+ T cells have been long known to play an important role in the pathogenesis of rheumatoid arthritis (RA), but the specific cell populations and states that drive the disease have been challenging to identify with low dimensional single cell data and bulk assays. The advent of high dimensional single cell technologies – like single cell RNA-seq or mass cytometry – has offered promise to defining key populations, but brings new methodological and statistical challenges. Recent single cell profiling studies have revealed a broad diversity of cell types among CD4+ T cells, identifying novel populations that are expanded or altered in RA. Here we will review recent findings on CD4+ T cell heterogeneity and RA that have come from single cell profiling studies and discuss the best practices for conducting these studies.
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影响因子：
16.8
作者：
Bendall SC;Nolan GP;Roederer M;Chattopadhyay PK
通讯作者：
Chattopadhyay PK
影响因子：
--
作者：
Cui, Jing;Saevarsdottir, Saedis;Thomson, Brian;Padyukov, Leonid;van der Helm-van Mil, Annette H. M.;Nititham, Joanne;Hughes, Laura B.;de Vries, Niek;Raychaudhuri, Soumya;Alfredsson, Lars;Askling, Johan;Wedren, Sara;Ding, Bo;Guiducci, Candace;Wolbink, Gert Jan;Crusius, J. Bart A.;van der Horst-Bruinsma, Irene E.;Herenius, Marieke;Weinblatt, Michael E.;Shadick, Nancy A.;Worthington, Jane;Batliwalla, Franak;Kern, Marlena;Morgan, Ann W.;Wilson, Anthony G.;Isaacs, John D.;Hyrich, Kimme;Seldin, Michael F.;Moreland, Larry W.;Behrens, Timothy W.;Allaart, Cornelia F.;Criswell, Lindsey A.;Huizinga, Tom W. J.;Tak, Paul P.;Bridges, S. Louis, Jr.;Toes, Rene E. M.;Barton, Anne;Klareskog, Lars;Gregersen, Peter K.;Karlson, Elizabeth W.;Plenge, Robert M.
通讯作者：
Plenge, Robert M.
影响因子：
3.2
作者：
DEAN, PN;PINKEL, D
通讯作者：
PINKEL, D
DOI：
10.1126/science.1198704
发表时间：
2011-05-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bendall SC;Simonds EF;Qiu P;Amir el-AD;Krutzik PO;Finck R;Bruggner RV;Melamed R;Trejo A;Ornatsky OI;Balderas RS;Plevritis SK;Sachs K;Pe'er D;Tanner SD;Nolan GP
通讯作者：
Nolan GP
影响因子：
48
作者：
Aghaeepour N;Finak G;FlowCAP Consortium;DREAM Consortium;Hoos H;Mosmann TR;Brinkman R;Gottardo R;Scheuermann RH
通讯作者：
Scheuermann RH