Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy.
Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy.
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DOI：
10.3390/ijms23031532
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发表时间：
2022-01-28
影响因子：
5.6
通讯作者：
Tchounwou PB
中科院分区：
文献类型：
--
作者：
Dasari S;Njiki S;Mbemi A;Yedjou CG;Tchounwou PB
顺铂和其他基于铂的药物，如卡铂、奥马铂和奥沙利铂，已被广泛用于治疗多种人类癌症。然而，相当大比例的患者经常由于对多个器官的耐药性和/或毒性而复发，包括肝脏、肾脏、胃肠道以及心血管、血液和神经系统。在这项研究中，我们试图对顺铂在癌症治疗中的应用现状进行全面的综述，特别强调顺铂的分子作用机制，以及包括与天然产物联合治疗的治疗方式。因此，我们利用各种科学数据库，如MEDLINE、PubMed、Google Scholar和相关来源检索文献，收集和综述有关顺铂、天然产物、联合疗法、在癌症治疗中的用途、作用方式和治疗策略的相关文献。我们的搜索结果显示，癌症治疗的新战略方法，包括顺铂和天然产品的联合治疗，已经得到了一定程度的成功评估。来自体外和体内研究的科学证据表明，许多药用植物含有生物活性化合物，这些化合物有望用于治疗人类疾病，因此是药物发现的极好来源。临床前研究表明，天然产物不仅能增强顺铂的治疗活性，还能减轻其化疗毒性。许多实验研究也报道，天然产物通过调节丝裂原活化蛋白激酶(MAPK)和P53信号转导通路以及增强顺铂的化疗敏感性而触发细胞凋亡，从而发挥其治疗作用。此外，天然产物通过调节几个基因转录因子和通过凋亡和/或坏死诱导细胞死亡来保护顺铂引起的器官毒性。此外，顺铂与聚合物、脂质、无机和碳基纳米药物递送系统的制剂已被发现可以延迟药物释放，延长半衰期，并降低全身毒性，而其他制剂，如纳米胶囊，纳米凝胶和水凝胶，已被报道增强细胞渗透，靶向癌细胞，并抑制肿瘤进展。
Cisplatin and other platinum-based drugs, such as carboplatin, ormaplatin, and oxaliplatin, have been widely used to treat a multitude of human cancers. However, a considerable proportion of patients often relapse due to drug resistance and/or toxicity to multiple organs including the liver, kidneys, gastrointestinal tract, and the cardiovascular, hematologic, and nervous systems. In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products. Hence, we searched the literature using various scientific databases., such as MEDLINE, PubMed, Google Scholar, and relevant sources, to collect and review relevant publications on cisplatin, natural products, combination therapy, uses in cancer treatment, modes of action, and therapeutic strategies. Our search results revealed that new strategic approaches for cancer treatment, including the combination therapy of cisplatin and natural products, have been evaluated with some degree of success. Scientific evidence from both in vitro and in vivo studies demonstrates that many medicinal plants contain bioactive compounds that are promising candidates for the treatment of human diseases, and therefore represent an excellent source for drug discovery. In preclinical studies, it has been demonstrated that natural products not only enhance the therapeutic activity of cisplatin but also attenuate its chemotherapy-induced toxicity. Many experimental studies have also reported that natural products exert their therapeutic action by triggering apoptosis through modulation of mitogen-activated protein kinase (MAPK) and p53 signal transduction pathways and enhancement of cisplatin chemosensitivity. Furthermore, natural products protect against cisplatin-induced organ toxicity by modulating several gene transcription factors and inducing cell death through apoptosis and/or necrosis. In addition, formulations of cisplatin with polymeric, lipid, inorganic, and carbon-based nano-drug delivery systems have been found to delay drug release, prolong half-life, and reduce systemic toxicity while other formulations, such as nanocapsules, nanogels, and hydrogels, have been reported to enhance cell penetration, target cancer cells, and inhibit tumor progression.
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影响因子：
4.2
作者：
Amagase, H
通讯作者：
Amagase, H
影响因子：
4
作者：
Abel Lozano-Perez, A.;Gil, Ana L.;Ruiz, Jose
通讯作者：
Ruiz, Jose
影响因子：
78.5
作者：
Chabner, BA;Roberts, TG
通讯作者：
Roberts, TG
影响因子：
3.3
作者：
Alara, Oluwaseun Ruth;Abdurahman, Nour Hamid;Kabbashi, Nassereldeen Ahmed
通讯作者：
Kabbashi, Nassereldeen Ahmed
DOI：
10.1111/j.1440-1681.2007.04714.x
发表时间：
2007-12-01
影响因子：
2.9
作者：
Aleisa, Abdulaziz M.;Al-Majed, Abdulhakeem A.;Sayed-Ahmed, Mohamed M.
通讯作者：
Sayed-Ahmed, Mohamed M.