RGD-binding integrins and TGF-β in SARS-CoV-2 infections - novel targets to treat COVID-19 patients?
RGD-binding integrins and TGF-β in SARS-CoV-2 infections - novel targets to treat COVID-19 patients?
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DOI：
10.1002/cti2.1240
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发表时间：
2021
影响因子：
5.8
通讯作者：
Piesche M
中科院分区：
文献类型：
--
作者：
Carvacho I;Piesche M
新型冠状病毒SARS - CoV - 2是一种全球性大流行和严重的公共卫生危机。SARS - CoV - 2具有高度传染性，死亡率高，特别是在老年人和已有疾病的患者中。在目前阶段，没有有效的药物可用于治疗这些患者。在这篇综述中，我们分析了靶向RGD结合整合素抑制病毒细胞感染和阻断TGF - β活化的基本原理，TGF - β活化与几种人类疾病的严重程度有关，包括严重的COVID - 19病例的并发症。此外，我们证明了ACE2和TGF - β表达与严重COVID - 19感染的可能后果之间的相关性。最后，我们列出了针对RGD结合整合素或TGF - β的其他疾病的批准药物或临床试验药物。这些药物已经显示出良好的安全性，因此可以更快地用于治疗COVID - 19患者的试验。SARS - CoV - 2具有高度传染性，死亡率很高，特别是在老年人和已有疾病的患者中。在这篇综述中，我们解释了靶向RGD结合整合素抑制病毒细胞感染和阻断TGF - b激活的基本原理，TGF - b激活与几种人类疾病的严重程度有关，包括严重的COVID - 19病例的并发症。
The new coronavirus SARS‐CoV‐2 is a global pandemic and a severe public health crisis. SARS‐CoV‐2 is highly contagious and shows high mortality rates, especially in elderly and patients with pre‐existing medical conditions. At the current stage, no effective drugs are available to treat these patients. In this review, we analyse the rationale of targeting RGD‐binding integrins to potentially inhibit viral cell infection and to block TGF‐β activation, which is involved in the severity of several human pathologies, including the complications of severe COVID‐19 cases. Furthermore, we demonstrate the correlation between ACE2 and TGF‐β expression and the possible consequences for severe COVID‐19 infections. Finally, we list approved drugs or drugs in clinical trials for other diseases that also target the RGD‐binding integrins or TGF‐β. These drugs have already shown a good safety profile and, therefore, can be faster brought into a trial to treat COVID‐19 patients. SARS‐CoV‐2 is highly contagious and shows high mortality rates especially in elderly and patients with pre‐existing medical conditions. In this review, we explain the rationale of targeting RGD‐binding integrins to potentially inhibit viral cell infection and to block TGF‐b activation, which is involved in the severity of several human pathologies, including the complications of severe COVID‐19 cases.
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影响因子：
3.2
作者：
BREUSS, JM;GILLETT, N;PYTELA, R
通讯作者：
PYTELA, R
DOI：
10.1101/2020.06.15.153387
发表时间：
2021-01-01
期刊：
JACC. Basic to translational science
影响因子：
--
作者：
Beddingfield, Brandon J;Iwanaga, Naoki;Bix, Gregory J
通讯作者：
Bix, Gregory J
影响因子：
10.9
作者：
Arnaldez, Fernanda, I;O'Day, Steven J.;Ascierto, Paolo Antonio
通讯作者：
Ascierto, Paolo Antonio
影响因子：
56.9
作者：
BROOKS, PC;CLARK, RAF;CHERESH, DA
通讯作者：
CHERESH, DA
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny