Discovery and development of natural product oridonin-inspired anticancer agents.
Discovery and development of natural product oridonin-inspired anticancer agents.
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DOI：
10.1016/j.ejmech.2016.06.015
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发表时间：
2016-10-21
影响因子：
6.7
通讯作者：
Zhou, Jia
中科院分区：
文献类型：
--
作者：
Ding, Ye;Ding, Chunyong;Ye, Na;Liu, Zhiqing;Wold, Eric A.;Chen, Haiying;Wild, Christopher;Shen, Qiang;Zhou, Jia
天然产品在历史上一直是，并将继续是，用于发现各种治疗剂的宝贵来源。冬凌草甲素是一种天然二萜类化合物，具有广泛的抗癌、抗炎等生物学活性。为了进一步提高其效力，水溶性和生物利用度，冬凌草甲素模板作为药物发现的一个令人兴奋的平台，以产生具有独特靶点和增强药物性质的更好的候选物。许多冬凌草甲素衍生物（如HAO 472）已被设计和合成，并在鉴定新药物和相关分子机制研究方面取得了实质性进展，用于治疗人类癌症和其他疾病。本文综述了近年来在药物化学方面对新型冬凌草甲素类似物作为潜在的抗癌药物的研究进展，并对这类分子的发展和临床应用的未来方向进行了详细的讨论。
Natural products have historically been, and continue to be, an invaluable source for the discovery of various therapeutic agents. Oridonin, a natural diterpenoid widely applied in traditional Chinese medicines, exhibits a broad range of biological effects including anticancer and anti-inflammatory activities. To further improve its potency, aqueous solubility and bioavailability, the oridonin template serves as an exciting platform for drug discovery to yield better candidates with unique targets and enhanced drug properties. A number of oridonin derivatives (e.g. HAO472) have been designed and synthesized, and have contributed to substantial progress in the identification of new agents and relevant molecular mechanistic studies toward the treatment of human cancers and other diseases. This review summarizes the recent advances in medicinal chemistry on the explorations of novel oridonin analogues as potential anticancer therapeutics, and provides a detailed discussion of future directions for the development and progression of this class of molecules into the clinic.
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影响因子：
6.7
作者：
Chen, Haijun;Yang, Zhengduo;Ding, Chunyong;Chu, Lili;Zhang, Yusong;Terry, Kristin;Liu, Huiling;Shen, Qiang;Zhou, Jia
通讯作者：
Zhou, Jia
影响因子：
3.2
作者：
Ding C;Wang L;Chen H;Wild C;Ye N;Ding Y;Wang T;White MA;Shen Q;Zhou J
通讯作者：
Zhou J
影响因子：
9.7
作者：
Chen, Haijun;Gao, Yu;Wu, Jianlei;Chen, Yingyu;Chen, Buyuan;Hu, Jianda;Zhou, Jia
通讯作者：
Zhou, Jia
DOI：
10.1016/j.jss.2015.07.042
发表时间：
2015-12
期刊：
The Journal of surgical research
影响因子：
--
作者：
Bohanon FJ;Wang X;Graham BM;Ding C;Ding Y;Radhakrishnan GL;Rastellini C;Zhou J;Radhakrishnan RS
通讯作者：
Radhakrishnan RS
影响因子：
7.3
作者：
Chen L;Zhang Y;Kong X;Lan E;Huang Z;Peng S;Kaufman DL;Tian J
通讯作者：
Tian J