Stimulation of the center of the lateral reticular nucleus suppresses the swallowing reflex in rats
Stimulation of the center of the lateral reticular nucleus suppresses the swallowing reflex in rats
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刺激外侧网状核中心抑制大鼠吞咽反射
DOI：
10.1016/j.neulet.2022.136998
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发表时间：
2023
影响因子：
2.5
通讯作者：
Ohkoshi Shogo
中科院分区：
文献类型：
--
作者：
Sakazume Tomohito;Satoh Yoshihide;Ohkoshi Shogo
形态学研究表明，外侧网状核（LRt）接受来自吞咽反射控制相关部位的纤维投射。虽然LRt因此可能与吞咽反射的控制有关，但LRt在吞咽反射中的功能作用尚不清楚。本研究考察了吞咽反射是否受到下颞叶刺激的调节。这些实验是在氨基甲酸乙酯麻醉的大鼠身上进行的。吞咽反射是通过重复电刺激喉上神经（SLN）引起的，并通过肌电图活动从下颌舌骨肌识别。在LRt上施加电刺激或在LRt上注射谷氨酸。在LRt的背侧方向中部附近进行电刺激时，燕子的数量减少，第一次燕子发作的潜伏期增加。在LRt的背侧中心附近微量注射谷氨酸后，吞咽次数减少，首次吞咽潜伏期增加。目前的研究表明，LRt参与了吞咽反射的控制。
Morphological studies have demonstrated that the lateral reticular nucleus (LRt) receives fibers projected from sites that are related to control of the swallowing reflex. Although the LRt may therefore be related to control of the swallowing reflex, the functional role of the LRt in the swallowing reflex remains unknown. The present study examined whether the swallowing reflex is modulated by stimulation of the LRt. These experiments were performed on rats anesthetized by urethane. The swallowing reflex was evoked by repetitive electrical stimulation of the superior laryngeal nerve (SLN) and was identified by electromyographic activities from the mylohyoid muscle. Electrical stimulation was applied to the LRt or glutamate was injected into the LRt. The number of swallows was reduced, and the latency of the onset of the first swallow was increased during electrical stimulation near the middle of the rostrocaudal direction of the LRt. The number of swallows was reduced, and the latency of onset of the first swallow increased after microinjection of glutamate near the rostrocaudal center of the LRt. The present study suggests that the LRt is involved in control of the swallowing reflex.
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作者：
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作者：
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DOI：
10.1002/lary.29242
发表时间：
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期刊：
The Laryngoscope
影响因子：
--
作者：
Kinoshita Shota;Sugiyama Yoichiro;Hashimoto Keiko;Fuse Shinya;Mukudai Shigeyuki;Umezaki Toshiro;Dutschmann Mathias;Hirano Shigeru
通讯作者：
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