Influences of GABAergic Inhibition in the Dorsal Medulla on Contralateral Swallowing Neurons in Rats
Influences of GABAergic Inhibition in the Dorsal Medulla on Contralateral Swallowing Neurons in Rats
复制标题
大鼠背髓质 GABA 能抑制对对侧吞咽神经元的影响
DOI：
10.1002/lary.29242
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Hirano Shigeru
中科院分区：
文献类型：
--
作者：
Kinoshita Shota;Sugiyama Yoichiro;Hashimoto Keiko;Fuse Shinya;Mukudai Shigeyuki;Umezaki Toshiro;Dutschmann Mathias;Hirano Shigeru
目的观察单侧抑制髓质背侧吞咽网络对吞咽相关颅运动神经和吞咽中间神经元活动的影响。方法观察25只幼年大鼠在对照组和脑干灌注预备液中微量注射GABA激动剂muscimol后，通过电刺激喉上神经引起的双侧迷走神经活动（VNA）和单侧膈、舌下活动（HNA）。同时记录20只大鼠对侧肌药侧吞咽中间神经元的胞外活动，分析其在吞咽过程中的放电频率。结果注射侧综合VNA和HNA分别降至49.0±16.6%和32.3±17.9%。注射muscimol后，未注射侧VNA变化不大。局部抑制后，20个对侧吞咽中间神经元中有11个在诱发吞咽过程中各自的放电增加或减少，而其余9个神经元的活动没有明显变化。结论脊髓背侧吞咽模式产生的神经网络调节同侧运动输出并调节对侧吞咽中间神经元的活动，表明吞咽中枢模式产生的双侧协调调节咽吞咽运动的时空组织。[j] .中华耳鼻喉科杂志，2016,31 (1):387 - 398
ObjectivesWe aimed to examine the effect of unilateral inhibition of the medullary dorsal swallowing networks on the activities of swallowing‐related cranial motor nerves and swallowing interneurons.MethodsIn 25 juvenile rats, we recorded bilateral vagal nerve activity (VNA) as well as unilateral phrenic and hypoglossal activity (HNA) during fictive swallowing elicited by electrical stimulation of the superior laryngeal nerve during control and following microinjection of the GABA agonist muscimol into the caudal dorsal medulla oblongata in a perfused brainstem preparation. In 20 animals, swallowing interneurons contralateral to the muscimol injection side were simultaneously recorded extracellularly and their firing rates were analyzed during swallowing.ResultsIntegrated VNA and HNA to the injection side decreased to 49.0 ± 16.6% and 32.3 ± 17.9%, respectively. However, the VNA on the uninjected side showed little change after muscimol injection. Following local inhibition, 11 out of 20 contralateral swallowing interneurons showed either increased or decreased of their respective firing discharge during evoked‐swallowing, while no significant changes in activity were observed in the remaining nine neurons.ConclusionThe neuronal networks underlying the swallowing pattern generation in the dorsal medulla mediate the ipsilateral motor outputs and modulate the contralateral activity of swallowing interneurons, suggesting that the bilateral coordination of the swallowing central pattern generator regulates the spatiotemporal organization of pharyngeal swallowing movements.Level of EvidenceNALaryngoscope, 131:2187–2198, 2021
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