Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism.
Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism.
复制标题
DOI：
10.1111/j.1471-4159.2010.06858.x
复制
发表时间：
2010-09-01
影响因子：
4.7
通讯作者：
Blatt GJ
中科院分区：
文献类型：
--
作者：
Oblak AL;Gibbs TT;Blatt GJ
自闭症是一种行为上的神经发育障碍，其症状包括面部和情绪处理障碍。新出现的证据表明，自闭症患者的GABA能（γ-氨基丁酸）系统异常，这可能导致这些缺陷。GABAB受体在调节突触和维持脑内兴奋-抑制平衡中起重要作用。GABAB受体在自闭症患者和对照组中的密度在前扣带皮层和后扣带皮层中进行定量，这对社会情绪和认知处理很重要，梭状回对面部和面部表情的识别很重要。GABAB受体密度显着减少，证明在所有三个地区的检查表明，在这个关键的抑制性受体亚型的改变可能有助于自闭症患者的功能缺陷。有趣的是，在自闭症病例的一个子集中癫痫发作的存在对三个区域中任何一个区域的GABAB受体密度没有显着影响。
Autism is a behaviorally defined neurodevelopmental disorder and among its symptoms are disturbances in face and emotional processing. Emerging evidence demonstrates abnormalities in the GABAergic (gamma-aminobutyric acid) system in autism, which likely contributes to these deficits. GABAB receptors play an important role in modulating synapses and maintaining the balance of excitation-inhibition in the brain. The density of GABAB receptors in subjects with autism and matched controls was quantified in the anterior and posterior cingulate cortex, important for socio-emotional and cognitive processing, and the fusiform gyrus, important for identification of faces and facial expressions. Significant reductions in GABAB receptor density were demonstrated in all three regions examined suggesting that alterations in this key inhibitory receptor subtype may contribute to the functional deficits in individuals with autism. Interestingly, the presence of seizure in a subset of autism cases did not have a significant effect on the density of GABAB receptors in any of the three regions.
登录
查看更多内容
影响因子：
14.5
作者：
Bailey, A;Luthert, P;Lantos, P
通讯作者：
Lantos, P
影响因子：
9.9
作者：
Casanova, MF;Buxhoeveden, DP;Roy, E
通讯作者：
Roy, E
影响因子：
2.3
作者：
Calon, F;Lavertu, N;Di Paolo, T
通讯作者：
Di Paolo, T
影响因子：
3.5
作者：
Chih, B;Afridi, SK;Scheiffele, P
通讯作者：
Scheiffele, P
影响因子：
6.9
作者：
Fombonne, E
通讯作者：
Fombonne, E